CAS 1926-49-4

Clometocillin

Description:

Clometocillin is a semisynthetic antibiotic belonging to the penicillin class, specifically designed to combat bacterial infections. It is characterized by its broad-spectrum activity against various Gram-positive and some Gram-negative bacteria. The compound features a beta-lactam ring, which is essential for its antibacterial properties, as it inhibits bacterial cell wall synthesis. Clometocillin is typically administered via injection and is known for its stability against certain beta-lactamases, enzymes produced by bacteria that can inactivate many penicillins. Its pharmacokinetics include rapid absorption and distribution in the body, with a relatively short half-life, necessitating multiple doses for effective treatment. Common side effects may include allergic reactions, gastrointestinal disturbances, and potential interactions with other medications. Due to the emergence of antibiotic resistance, the use of Clometocillin and similar antibiotics is often guided by susceptibility testing to ensure efficacy against the targeted pathogens. Overall, Clometocillin represents an important tool in the arsenal against bacterial infections, although its use must be carefully monitored to mitigate resistance development.

Formula: C₁₇H₁₈Cl₂N₂O₅S

InChI: InChI=1S/C17H18Cl2N2O5S/c1-17(2)12(16(24)25)21-14(23)10(15(21)27-17)20-13(22)11(26-3)7-4-5-8(18)9(19)6-7/h4-6,10-12,15H,1-3H3,(H,20,22)(H,24,25)/t10-,11?,12+,15-/m1/s1

InChI key: InChIKey=JKXQBIZCQJLVOS-GSNLGQFWSA-N

SMILES: N(C(C(OC)C1=CC(Cl)=C(Cl)C=C1)=O)[C@H]2[C@@]3(N([C@@H](C(O)=O)C(C)(C)S3)C2=O)[H]

Synonyms:

• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(3,4-dichlorophenyl)methoxyacetyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• (2S,5R,6R)-6-[[2-(3,4-Dichlorophenyl)-2-methoxyacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(3,4-dichlorophenyl)methoxyacetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[2-(3,4-dichlorophenyl)-2-methoxyacetamido]-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[2-(3,4-dichlorophenyl)-2-methoxyacetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-

Clometocillin

CAS: 1926-49-4

Clometocillin is a penicillin that can active penicillin to pen-I or pen-R pneumococci.

Formula: C₁₇H₁₈Cl₂N₂O₅S

Color and Shape: Solid

Molecular weight: 433.31

Ref: TM-T30981