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CAS 1926-94-9

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dexamethasone 21-pivalate

Description:
Dexamethasone 21-pivalate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is a derivative of dexamethasone, modified by the addition of a pivalate group at the 21 position, which enhances its lipophilicity and prolongs its action. This compound is typically used in various therapeutic applications, including the treatment of inflammatory conditions, allergies, and certain autoimmune disorders. Dexamethasone 21-pivalate exhibits a high affinity for glucocorticoid receptors, leading to its potent effects on gene expression and cellular responses. It is characterized by its stability and solubility in organic solvents, while being less soluble in water. The compound is often administered via topical, oral, or injectable routes, depending on the clinical indication. As with other corticosteroids, its use may be associated with side effects, particularly with long-term administration, including potential suppression of the hypothalamic-pituitary-adrenal (HPA) axis. Proper dosing and monitoring are essential to minimize adverse effects while maximizing therapeutic benefits.
Formula:C27H37FO6
InChI:InChI=1/C27H37FO6/c1-15-11-19-18-8-7-16-12-17(29)9-10-24(16,5)26(18,28)20(30)13-25(19,6)27(15,33)21(31)14-34-22(32)23(2,3)4/h9-10,12,15,18-20,30,33H,7-8,11,13-14H2,1-6H3/t15-,18+,19+,20+,24+,25+,26+,27+/m1/s1
InChI key:InChIKey=XMQRFWOHEPJZPS-JHUFMRCFSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COC(C(C)(C)C)=O)=O)O)[H]
Synonyms:
  • (11Beta,16Alpha)-9-Fluoro-11,17-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 2,2-Dimethylpropanoate
  • (11β,16α)-21-(2,2-Dimethyl-1-oxopropoxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Dexamethasone 21-trimethylacetate
  • Dexamethasone Pivalate
  • Dexamethasone trimethylacetate
  • Opticortenol
  • Pivalic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-pivalate
  • dexamethasone 21-pivalate
  • See more synonyms
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