CAS 19262-68-1

Focalin

Description:

Focalin is the brand name for the pharmaceutical compound dexmethylphenidate, which is primarily used in the treatment of attention deficit hyperactivity disorder (ADHD). It is a central nervous system stimulant that functions by increasing the levels of certain neurotransmitters in the brain, particularly dopamine and norepinephrine. The chemical structure of dexmethylphenidate is characterized by its methylphenidate backbone, with a specific focus on the dextrorotatory enantiomer, which is believed to be more pharmacologically active than its counterpart. Focalin is typically administered in its hydrochloride salt form and is available in both immediate-release and extended-release formulations. Common side effects may include insomnia, decreased appetite, and increased heart rate. As with other stimulant medications, it is classified as a Schedule II controlled substance due to its potential for abuse and dependence. Proper medical supervision is essential when using Focalin to manage ADHD symptoms effectively while minimizing risks.

Formula: C₁₄H₁₉NO₂·ClH

InChI: InChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H/t12-,13-;/m1./s1

InChI key: InChIKey=JUMYIBMBTDDLNG-OJERSXHUSA-N

SMILES: [C@@H](C(OC)=O)(C1=CC=CC=C1)[C@]2(CCCCN2)[H].Cl

Synonyms:

• (2R,2'R)-(+)-threo-Methyl a-Phenyl-a-(2-piperidyl)acetate Hydrochloride
• 2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride (1:1), (αR,2R)-
• 2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride, (αR,2R)-
• 2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride, [R-(R*,R*)]-
• <span class="text-smallcaps">D</span>-threo-Methylphenidate hydrochloride
• D-Methylphenidate
• Dexmethylphenidate Hydrochloride
• Focalin
• methyl (2R)-phenyl[(2R)-piperidin-2-yl]ethanoate
• methyl (2R)-phenyl[(2R)-piperidin-2-yl]ethanoate Hydrochloride (1:1)
• d-threo-Methylphenidate hydrochloride

Dexmethylphenidate Hydrochloride

Controlled Product

CAS: 19262-68-1

Color and Shape: Neat

Ref: 86-MM3537.00

D-threo-Methylphenidate Hydrochloride

Controlled Product

CAS: 19262-68-1

Applications Controlled substance. CNS stimulant. The more potent isomers of Methylphenidate. The threo enantomers have shown that the pharmacological activity residues predominantly in the d-threo enantiomer.
References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),

Formula: C₁₄H₁₉NO₂·ClH

Color and Shape: White To Off-White

Molecular weight: 269.77

Ref: TR-M325675

D-threo-Methylphenidate-d10 Hydrochloride (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 19262-68-1

Formula: C₁₄H₉D₁₀NO₂•HCl

Color and Shape: Single Solution

Molecular weight: 243.373646

Ref: TR-KIT6075

D-threo-Methylphenidate-d10 Hydrochloride

Controlled Product

CAS: 19262-68-1

Applications D-threo-Methylphenidate-d10 Hydrochloride is labelled D-threo-Methylphenidate Hydrochloride (M325675) which has shown that the pharmacological activity residues predominantly in the d-threo enantiomer.
References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),

Formula: C₁₄H₉D₁₀NO₂•HCl

Color and Shape: Neat

Molecular weight: 243.373646

Ref: TR-M325677