CAS 192705-80-9

N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea

Description:

N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea, with CAS number 192705-80-9, is a synthetic organic compound characterized by its complex structure, which includes multiple functional groups such as urea, amine, and aromatic rings. This compound exhibits significant biological activity, often studied for its potential as a pharmaceutical agent, particularly in the context of cancer treatment. Its molecular structure suggests it may interact with specific biological targets, influencing cellular pathways. The presence of dichlorophenyl and diethylamino groups indicates potential lipophilicity, which can affect its absorption and distribution in biological systems. Additionally, the pyrido[2,3-d]pyrimidine core contributes to its pharmacological properties. Safety and handling precautions are essential due to its chemical nature, and it is typically handled in controlled laboratory environments. Overall, this compound represents a class of molecules that are of interest in medicinal chemistry and drug development.

Formula: C₂₆H₃₅Cl₂N₇O

InChI: InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36)

InChI key: InChIKey=MKVMEJKNLUWFSQ-UHFFFAOYSA-N

SMILES: N(C(NC(C)(C)C)=O)C=1C(=CC2=C(N1)N=C(NCCCCN(CC)CC)N=C2)C3=C(Cl)C=CC=C3Cl

Synonyms:

• Urea, N-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)-
• 1-tert-Butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]urea
• PD 161570
• N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea

1-Tert-Butyl-3-[6-(2,6-Dichlorophenyl)-2-[[4-(Diethylamino)Butyl]Amino]Pyrido[2,3-D]Pyrimidin-7-Yl]Urea

CAS: 192705-80-9

1-Tert-Butyl-3-[6-(2,6-Dichlorophenyl)-2-[[4-(Diethylamino)Butyl]Amino]Pyrido[2,3-D]Pyrimidin-7-Yl]Urea

Purity: 98%

Molecular weight: 532.51g/mol

Ref: 54-OR1023262

PD-161570

CAS: 192705-80-9

Formula: C₂₆H₃₅Cl₂N₇O

Molecular weight: 532.51

Ref: 7W-GK1187

PD-161570

CAS: 192705-80-9

PD-161570

Purity: ≥98%

Molecular weight: 532.51g/mol

Ref: 54-BUP08246

PD-161570

CAS: 192705-80-9

Formula: C₂₆H₃₅Cl₂N₇O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 532.51

Ref: 3B-P2531

PD-161570

CAS: 192705-80-9

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.

Formula: C₂₆H₃₅Cl₂N₇O

Purity: 99.92%

Color and Shape: Solid

Molecular weight: 532.51

Ref: TM-T23127

PD-161570

Controlled Product

CAS: 192705-80-9

Applications PD-161570 is a novel FGF-1 receptor tyrosine kinase inhibitor, which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells (1,2,3).
References (1) Nandi, S. et al.: J. Enz. Inhib. Med. Chem., 24, 937 (2009)(2) Batley, B. L. et al.: Life Sci., 62, 143 (1998) (3) Hamby, J.M. et al.: J. Med. Chem., 40, 2296 (1997)

Formula: C₂₆H₃₅Cl₂N₇O

Color and Shape: Neat

Molecular weight: 532.51

Ref: TR-P217490

PD 161570

CAS: 192705-80-9

Inhibitor of FGF-1 receptor tyrosine kinase

Formula: C₂₆H₃₅Cl₂N₇O

Purity: Min. 95%

Molecular weight: 532.51 g/mol

Ref: 3D-FP26775