CAS 192725-39-6

Lopinavir Metabolite M-1

Description:

Lopinavir Metabolite M-1, identified by its CAS number 192725-39-6, is a significant metabolite of the antiretroviral drug Lopinavir, which is primarily used in the treatment of HIV/AIDS. This metabolite is formed through the metabolic processes in the liver, primarily by cytochrome P450 enzymes. Characteristically, Lopinavir Metabolite M-1 retains some antiviral activity, although it is generally less potent than the parent compound, Lopinavir. The substance is typically characterized by its chemical structure, which includes a complex arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its origin from a larger, more complex molecule. Its solubility and stability can vary based on environmental conditions, such as pH and temperature. Understanding the pharmacokinetics and dynamics of this metabolite is crucial for evaluating the overall efficacy and safety of Lopinavir in therapeutic regimens. Additionally, the study of its interactions with other drugs is important for managing potential side effects and optimizing treatment outcomes in patients.

Formula: C₃₇H₄₆N₄O₆

InChI: InChI=1/C37H46N4O6/c1-24(2)34(41-19-18-32(43)40-37(41)46)36(45)38-29(20-27-14-7-5-8-15-27)22-31(42)30(21-28-16-9-6-10-17-28)39-33(44)23-47-35-25(3)12-11-13-26(35)4/h5-17,24,29-31,34,42H,18-23H2,1-4H3,(H,38,45)(H,39,44)(H,40,43,46)/t29?,30?,31-,34-/m0/s1

SMILES: CC(C)[C@@H](C(=NC(Cc1ccccc1)C[C@@H](C(Cc1ccccc1)N=C(COc1c(C)cccc1C)O)O)O)N1CCC(=NC1=O)O

Synonyms:

• (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- d
• (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- de

Lopinavir Metabolite M1

CAS: 192725-39-6

Formula: C₃₇H₄₆N₄O₆

Color and Shape: White To Off-White Solid

Molecular weight: 642.80

Ref: 4Z-L-305

Lopinavir Metabolite M-1

CAS: 192725-39-6

Lopinavir Metabolite M-1, derived from Lopinavir, inhibits HIV protease (Ki=0.7 pM) and shows antiviral activity in vitro.

Formula: C₃₇H₄₆N₄O₆

Color and Shape: Solid

Molecular weight: 642.78

Ref: TM-T39345

Lopinavir Metabolite M-1

Controlled Product

CAS: 192725-39-6

Applications A major metabolite of Lopinavir (L469480) . It is a COVID19-related research product.
References Molla, A., et al.: J. Virology, 250, 255 (1998), Sham, H., et al.: Antimicrob. Agents Chemother., 42, 3218 (1998), Kumar, G., et al.: Drug Metab. Dispos., 27, 86 (1999),

Formula: C₃₇H₄₆N₄O₆

Color and Shape: Neat

Molecular weight: 642.78

Ref: TR-L469485

Lopinavir metabolite M-1

CAS: 192725-39-6

Lopinavir M-1 is a metabolite of lopinavir, which is an HIV protease inhibitor. Lopinavir M-1 has been shown to have antiviral activity against HIV-1 and other retroviruses. It is a versatile building block that can be used as a reagent or a complex compound in the synthesis of other compounds. Lopinavir M-1 also has antiviral activity against HIV-2 and SIV, but not against the influenza virus.

Formula: C₃₇H₄₆N₄O₆

Purity: Min. 95%

Molecular weight: 642.78 g/mol

Ref: 3D-FL24927