CAS 192755-52-5

(3S,11S)-N-[(2R,3S)-2-ethoxy-5-oxo-oxolan-3-yl]-3-(isoquinoline-1-carbonylamino)-2,6-dioxo-1,7-diazabicyclo[5.4.0]undecane-11-carboxamide

Description:

The chemical substance with the name "(3S,11S)-N-[(2R,3S)-2-ethoxy-5-oxo-oxolan-3-yl]-3-(isoquinoline-1-carbonylamino)-2,6-dioxo-1,7-diazabicyclo[5.4.0]undecane-11-carboxamide" and CAS number "192755-52-5" is a complex organic compound characterized by its unique bicyclic structure and multiple functional groups. This compound features a diazabicyclo framework, which contributes to its potential biological activity. The presence of an isoquinoline moiety suggests possible interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the ethoxy and oxolan groups indicate that it may exhibit solubility in organic solvents and could participate in various chemical reactions. The specific stereochemistry denoted by the (3S,11S) and (2R,3S) configurations implies that the compound may have distinct spatial arrangements that influence its reactivity and biological interactions. Overall, this compound's intricate structure and functional diversity suggest potential applications in pharmaceuticals or as a research tool in biochemical studies.

Formula: C₂₆H₂₉N₅O₇

InChI: InChI=1/C26H29N5O7/c1-2-37-26-18(14-21(33)38-26)29-23(34)19-8-5-13-30-20(32)10-9-17(25(36)31(19)30)28-24(35)22-16-7-4-3-6-15(16)11-12-27-22/h3-4,6-7,11-12,17-19,26H,2,5,8-10,13-14H2,1H3,(H,28,35)(H,29,34)/t17-,18-,19-,26+/m0/s1

Synonyms:

• Pralnacasan [INN]
• (1S,9S)-N-((2R,3S)-2-Ethoxy-5-oxotetrahydrofuran-3-yl)-9-((isoquinolin-1-ylcarbonyl)amino)-6,10-dioxooctahydro-6-H-pyridazino(1,2-a)(1,2)diazepine-1-carboxamide
• Hmr 3480
• Pralnacasan
• Unii-N986Ni319S
• Vx 470
• 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxamide, N-((2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl)octahydro-9-((1-isoquinolinylcarbonyl)amino)-6,10-dioxo-, (1S,9S)-

Pralnacasan

CAS: 192755-52-5

Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).

Formula: C₂₆H₂₉N₅O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 523.54

Ref: TM-T16570

Pralnacasan

CAS: 192755-52-5

Pralnacasan is an inhibitor that has been shown to induce apoptosis in cancer cells. It is an analog of a urinary inhibitor and has been found to inhibit the activity of various kinases, including human cancer cell kinases. Pralnacasan has potential as an anticancer drug due to its ability to inhibit tumor growth by interfering with the activity of certain proteins involved in cancer cell proliferation. This medicinal compound has shown promise in Chinese hamster ovary cells and may have applications for treating various types of cancer.

Formula: C₂₆H₂₉N₅O₇

Purity: Min. 95%

Molecular weight: 523.5 g/mol

Ref: 3D-SHA75552