CAS 192939-46-1
:Ximelagatran
Description:
Ximelagatran is an anticoagulant medication that was developed as an alternative to traditional anticoagulants like warfarin. It is a direct thrombin inhibitor, which means it works by directly inhibiting the activity of thrombin, an enzyme crucial for blood clot formation. Ximelagatran is characterized by its oral bioavailability, which allows for convenient administration without the need for routine monitoring of coagulation parameters, unlike warfarin. The substance is a prodrug, meaning it is metabolized in the body to its active form, which exerts the anticoagulant effect. Its pharmacokinetic profile includes rapid absorption and a relatively short half-life, necessitating twice-daily dosing. However, despite its advantages, ximelagatran was associated with liver toxicity in some patients, leading to its withdrawal from the market. The compound's chemical structure includes a unique combination of functional groups that contribute to its pharmacological activity. Overall, ximelagatran represents an important step in the development of anticoagulant therapies, although its clinical use has been limited due to safety concerns.
Formula:C24H35N5O5
InChI:InChI=1S/C24H35N5O5/c1-2-34-20(30)15-26-21(17-6-4-3-5-7-17)24(32)29-13-12-19(29)23(31)27-14-16-8-10-18(11-9-16)22(25)28-33/h8-11,17,19,21,26,33H,2-7,12-15H2,1H3,(H2,25,28)(H,27,31)/t19-,21+/m0/s1
InChI key:InChIKey=ZXIBCJHYVWYIKI-PZJWPPBQSA-N
SMILES:C([C@H](NCC(OCC)=O)C1CCCCC1)(=O)N2[C@H](C(NCC3=CC=C(C(NO)=N)C=C3)=O)CC2
Synonyms:- Exanta/Ximelegatran
- Glycine, N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]-, ethyl ester
- H 376/95
- N-[(1R)-1-Cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]glycine Ethyl Ester
- Ximelagatran
- Ximelegatran
- ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate
- Exanta
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Found 6 products.
Ximelagatran
CAS:Ximelagatran, oral direct thrombin inhibitor, transforms to active melagatran in body.Formula:C24H35N5O5Purity:95.48% - 99.60%Color and Shape:SolidMolecular weight:473.57Ximelagatran
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An orally active direct thrombin inhibitor; prodrug of Melagatran. Antithrombotic.<br>References Owens, P.K., et al.: J. Pharm. Biomed. Anal., 27, 587 (2002), Kalus, J.S., et al.: Expert Opin. Invest. Drugs, 13, 465 (2004), Boos, C.J., et al.: Eur. J. Int. Med., 16, 267 (2005), Cullberg, M., et al.: Clin. Pharmacol. Ther., 77, 279 (2005),<br></p>Formula:C24H35N5O5Color and Shape:NeatMolecular weight:473.57Ximelagatran-d11
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An orally active direct thrombin inhibitor; prodrug of Melagatran. Antithrombotic.<br>References Owens, P.K., et al.: J. Pharm. Biomed. Anal., 27, 587 (2002), Kalus, J.S., et al.: Expert Opin. Invest. Drugs, 13, 465 (2004), Boos, C.J., et al.: Eur. J. Int. Med., 16, 267 (2005), Cullberg, M., et al.: Clin. Pharmacol. Ther., 77, 279 (2005),<br></p>Formula:C24H24D11N5O5Color and Shape:NeatMolecular weight:484.63Ximelagatran
CAS:<p>Ximelagatran is a coumarin derivative that inhibits the enzyme thrombin by binding to its active site. It has been shown to be an effective anticoagulant for the prevention of deep vein thrombosis and pulmonary embolism. Ximelagatran is converted in vivo to its active form, melagatran, which has been shown to have inhibitory properties on human coagulation factor VIIa. Ximelagatran also has a long half-life and does not require regular dosing.</p>Formula:C24H35N5O5Purity:Min. 95%Molecular weight:473.57 g/mol
