CAS 193022-04-7

4-[4-(4-Chlorophenoxy)phenylsulfonylmethyl]tetrahydropyran-4-carbohydroxamic acid

Description:

4-[4-(4-Chlorophenoxy)phenylsulfonylmethyl]tetrahydropyran-4-carbohydroxamic acid, with the CAS number 193022-04-7, is a chemical compound characterized by its complex structure, which includes a tetrahydropyran ring, a hydroxamic acid functional group, and a sulfonylmethyl linkage. This compound features a chlorophenoxy group that contributes to its potential biological activity, possibly influencing its interactions with various biological targets. Hydroxamic acids are known for their ability to chelate metal ions and can exhibit various pharmacological properties, including anti-cancer and anti-inflammatory activities. The presence of the sulfonyl group may enhance solubility and stability, making it a candidate for further research in medicinal chemistry. Its unique structural features suggest potential applications in drug development, particularly in the design of inhibitors targeting specific enzymes or receptors. However, detailed studies on its biological activity, toxicity, and pharmacokinetics would be necessary to fully understand its potential uses and safety profile.

Formula: C₁₉H₂₀ClNO₆S

InChI: InChI=1/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)

SMILES: c1cc(ccc1Cl)Oc1ccc(cc1)S(=O)(=O)CC1(CCOCC1)C(=NO)O

Synonyms:

• Ro-1130830
• Rs-130830
• 4-[4-(4-Chlorophenoxy)phenylsulfonylmethyl]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
• 4-({[4-(4-chlorophenoxy)phenyl]sulfonyl}methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide

4-(((4-(4-Chlorophenoxy)phenyl)sulfonyl)methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide

CAS: 193022-04-7

4-(((4-(4-Chlorophenoxy)phenyl)sulfonyl)methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide

Purity: 99%

Molecular weight: 425.89g/mol

Ref: 54-OR1074860

CTS-1027

CAS: 193022-04-7

CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.

Formula: C₁₉H₂₀ClNO₆S

Color and Shape: Solid

Molecular weight: 425.88

Ref: TM-T15015

CTS-1027

CAS: 193022-04-7

CTS-1027 is a metalloprotease inhibitor that blocks the activity of matrix metalloprotease. CTS-1027 has been shown to inhibit HIV and also prevents tumor growth in mice. In vitro assays have shown that CTS-1027 inhibits the production of matrix metalloproteinase, which is associated with collagen degradation. The mechanism by which CTS-1027 inhibits matrix metalloproteinase is not known. This drug also has neuropathological effects, including the reduction of amyloid beta peptides in a mouse model of Alzheimer's disease. It also reduces the amount of amyloid beta peptides in a mouse model of Parkinson's disease and reduces the number of pathological cardiac cells in vivo models. Solid-phase synthesis was used to produce this compound at high purity levels.

Formula: C₁₉H₂₀ClNO₆S

Purity: Min. 95%

Molecular weight: 425.88 g/mol

Ref: 3D-THA02204