CAS 193079-69-5

Tabimorelin

Description:

Tabimorelin, with the CAS number 193079-69-5, is a synthetic peptide that functions as a growth hormone secretagogue. It is primarily used in research settings to stimulate the release of growth hormone from the pituitary gland. Tabimorelin acts on the ghrelin receptor, mimicking the action of ghrelin, a hormone that plays a crucial role in regulating appetite and energy balance. This compound is characterized by its ability to enhance growth hormone levels, which can have implications in various therapeutic areas, including growth hormone deficiency and metabolic disorders. Tabimorelin is typically administered via injection and has been studied for its potential effects on body composition, muscle mass, and overall metabolic health. Its pharmacokinetics and safety profile are subjects of ongoing research, and while it shows promise, further studies are necessary to fully understand its efficacy and potential applications in clinical practice. As with any peptide, stability, storage conditions, and proper handling are essential for maintaining its integrity and effectiveness.

Formula: C₃₂H₄₀N₄O₃

InChI: InChI=1S/C32H40N4O3/c1-32(2,33)19-11-16-29(37)35(4)28(22-24-17-18-25-14-9-10-15-26(25)20-24)31(39)36(5)27(30(38)34-3)21-23-12-7-6-8-13-23/h6-18,20,27-28H,19,21-22,33H2,1-5H3,(H,34,38)/b16-11+/t27-,28-/m1/s1

InChI key: InChIKey=WURGZWOTGMLDJP-ZCYANPAGSA-N

SMILES: [C@@H](CC1=CC2=C(C=C1)C=CC=C2)(C(N([C@H](CC3=CC=CC=C3)C(NC)=O)C)=O)N(C(/C=C/CC(C)(C)N)=O)C

Synonyms:

• (R)-alpha-((E)-5-Amino-N,5-dimethyl-2-hexenamido)-N-methyl-N-((R)-alpha-(methylcarbamoyl)phenethyl)-2-naphthalenepropionamide
• <span class="text-smallcaps">D</smallcap>-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-<smallcap>D</span>-alanyl-N,N^α-dimethyl-
• <span class="text-smallcaps">D</smallcap>-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-<smallcap>D</span>-alanyl-N,N^α-dimethyl-
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-<span class="text-smallcaps">D</smallcap>-alanyl-N,N^α-dimethyl-<smallcap>D</span>-phenylalaninamide
• N-[(2E)-5-amino-5-methylhex-2-enoyl]-N-methyl-3-(naphthalen-2-yl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide
• Nn 703
• Nnc 26-0703
• Tabimorelin [INN]
• Unii-L51Cbe03Kf
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide
• Tabimorelin
• D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-
• D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamidehemifumarate
• NNC26-0703
• N-[5-Amino-5-Methyl-2(E)-Hexenoyl]-N-Methyl-3-(2- Naphthyl)-D-Alanyl-N-Methyl-D-Phenylalanine Methylamide
• NNC-260703

Tabimorelin

CAS: 193079-69-5

Formula: C₃₂H₄₀N₄O₃

Molecular weight: 528.70

Ref: 4Z-T-172001

Tabimorelin

Controlled Product

CAS: 193079-69-5

Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.
References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),

Formula: C₃₂H₄₀N₄O₃

Color and Shape: Neat

Molecular weight: 528.68

Ref: TR-T003500

Tabimorelin

CAS: 193079-69-5

Tabimorelin is a potent analog of the endogenous hormone ghrelin. It binds to the ghrelin receptor and stimulates appetite, thereby increasing food intake and weight gain. Tabimorelin also has been shown to be effective in treating bowel disease, diabetic neuropathy, and symptoms of inflammatory bowel disease. The pharmacological effects of tabimorelin are due to its ability to bind to receptors in the gastrointestinal tract. This drug also has an effect on coordination complex formation by human liver microsomes. Tabimorelin can be used as a diagnostic tool for some types of cancer because it is not metabolized by enzymes in healthy cells, but is metabolized by enzymes in cancer cells. The use of tabimorelin as an analytical method is based on its ability to form coordination complexes with heavy metals such as mercury or lead.

Formula: C₆₈H₈₄N₈O₁₀

Purity: Min. 95%

Molecular weight: 1,173.4 g/mol

Ref: 3D-THA07969