CAS 19316-85-9

5'-AZIDO-5'-DEOXYTHYMIDINE

Description:

5'-Azido-5'-deoxythymidine, commonly referred to as AZT or zidovudine, is a nucleoside analog with significant antiviral properties, particularly against HIV. It is characterized by the presence of an azido group (-N3) at the 5' position of the deoxythymidine molecule, which replaces the hydroxyl group typically found in natural nucleosides. This modification enhances its ability to inhibit reverse transcriptase, an enzyme critical for viral replication. AZT is a white to off-white crystalline powder that is soluble in water and exhibits a molecular formula that reflects its nucleoside structure. Its mechanism of action involves incorporation into viral DNA, leading to chain termination during DNA synthesis. AZT is used clinically in the treatment of HIV/AIDS and is often part of combination therapy regimens. However, it can have side effects, including bone marrow suppression and gastrointestinal issues. As a result, monitoring and management of these effects are essential during treatment. Overall, 5'-azido-5'-deoxythymidine represents a crucial advancement in antiviral therapy.

Formula: C₁₀H₁₃N₅O₄

InChI: InChI=1/C10H13N5O4/c1-5-4-15(10(18)13-9(5)17)8-2-6(16)7(19-8)3-12-14-11/h4,6-8,11,16H,2-3H2,1H3/p+1

Synonyms:

• 5'-Azido-5'-Deoxy-D-Thymidine
• 1-(2,5-dideoxy-5-triaza-1,2-dien-2-ium-1-ylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• NSC 254064
• 5'-AZIDO-5'-DEOXYTHYMIDINE
• 1-((2R,4S,5R)-5-(azidoMethyl)-4-hydroxytetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 5'-AZT

5''-Azido-5''-deoxythymidine

CAS: 19316-85-9

Formula: C₁₀H₁₃N₅O₄

Purity: ≥ 95.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 267.24

Ref: 7W-GN6327

5'-Azido-5'-deoxythymidine

CAS: 19316-85-9

5'-Azido-5'-deoxythymidine

Purity: ≥98%

Molecular weight: 267.24g/mol

Ref: 54-BUP20102

5'-Azido-5'-deoxythymidine

CAS: 19316-85-9

5'-Azido-5'-deoxythymidine is a nucleoside analog with potential anti-tuberculosis activity and an inhibitor of TMPKmt in Mycobacterium tuberculosis.

Formula: C₁₀H₁₃N₅O₄

Purity: 99.85%

Color and Shape: Solid

Molecular weight: 267.24

Ref: TM-TNU1149

5-Azido-5-deoxy Thymidine

CAS: 19316-85-9

Formula: C₁₀H₁₃N₅O₄

Molecular weight: 267.25

Ref: 4Z-T-583

5'-Azido-5'-deoxythymidine

CAS: 19316-85-9

5'-Azido-5'-deoxythymidine is a synthetic analogue of thymidine. The compound has been synthesised and fluorescently labelled with ferrocene. 5'-Azido-5'-deoxythymidine is not cytotoxic to cancer cells, but it is shown to be an effective inhibitor of DNA synthesis by binding to the enzyme DNA polymerase. This causes a decrease in the rate of DNA synthesis and thus inhibits cancer cell growth.

Formula: C₁₀H₁₃N₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 267.24 g/mol

Ref: 3D-NA06452

5'-Azido-5'-deoxythymidine-d3

Controlled Product

CAS: 19316-85-9

Formula: C₁₀D₃H₁₀N₅O₄

Color and Shape: Neat

Molecular weight: 270.26

Ref: TR-A825102

5’-Azido-(5’-deoxy)thymidine

Controlled Product

CAS: 19316-85-9

Formula: C₁₀H₁₃N₅O₄

Color and Shape: Neat

Molecular weight: 267.241

Ref: TR-A825100