CAS 193275-84-2: LONAFARNIB

Description: Lonafarnib is a synthetic organic compound classified as a farnesyltransferase inhibitor, primarily used in the context of cancer treatment and certain viral infections. It is characterized by its ability to inhibit the farnesylation of proteins, a post-translational modification critical for the function of various oncogenic proteins, including Ras. The molecular structure of Lonafarnib includes a farnesyl moiety, which is essential for its mechanism of action. It is typically administered orally and has been investigated for its efficacy in treating various malignancies, particularly in patients with specific genetic mutations. Lonafarnib has also shown potential in treating diseases caused by certain viruses, such as the progeria syndrome. Its pharmacokinetics involve metabolism primarily through the liver, and it may exhibit interactions with other medications due to its effects on cytochrome P450 enzymes. Common side effects can include gastrointestinal disturbances and fatigue. Overall, Lonafarnib represents a targeted therapeutic approach in oncology and virology, highlighting the importance of protein modification in disease progression.

Formula: C₂₇H₃₁Br₂ClN₄O₂

InChI: InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1

InChI key: InChIKey=DHMTURDWPRKSOA-RUZDIDTESA-N

SMILES: O=C(N)N1CCC(CC(=O)N2CCC(CC2)C3C4=NC=C(Br)C=C4CCC=5C=C(Cl)C=C(Br)C53)CC1

Synonyms:

• ( )4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta (1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxami de
• 1-Piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-
• 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
• Sarasar
• Sch 66336
• Zokinvy

LONAFARNIB

CAS: 193275-84-2

• Formula: C₂₇H₃₁Br₂ClN₄O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 638.8216

(R)-4-(2-(4-(3,10-Dibromo-8-Chloro-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-b]Pyridin-11-yl)Piperidin-1-yl)-2-Oxoethyl)Piperidine-1-Carboxamide

CAS: 193275-84-2

• Purity: 99%
• Molecular weight: 638.82g/mol

Lonafarnib

CAS: 193275-84-2

• Purity: 99.03%
• Molecular weight: 638.82g/mol

Lonafarnib

CAS: 193275-84-2

• Formula: C₂₇H₃₁Br₂ClN₄O₂
• Color and Shape: Off-White Solid
• Molecular weight: 638.83

Lonafarnib-d9

CAS: 193275-84-2

• Formula: C₂₇H₂₂Br₂ClN₄O₂D₉
• Molecular weight: 647.89

Lonafarnib

CAS: 193275-84-2

Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 …

• Formula: C₂₇H₃₁Br₂ClN₄O₂
• Purity: 98% - 99.04%
• Color and Shape: Solid
• Molecular weight: 638.82

Lonafarnib

CAS: 193275-84-2

Lonafarnib is a selective, non-peptidomimetic competitive inhibitor of farnesyl trasferase with IC50 of 1.9nM. Farneslyl …

• Formula: C₂₇H₃₁Br₂ClN₄O₂
• Purity: Min. 95%
• Molecular weight: 638.82 g/mol

Lonafarnib-d9

CAS: 193275-84-2

• Formula: C₂₇D₉H₂₂Br₂ClN₄O₂
• Color and Shape: Neat
• Molecular weight: 647.877

Lonafarnib

CAS: 193275-84-2

Applications Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb …

• Formula: C₂₇H₃₁Br₂ClN₄O₂
• Color and Shape: Neat
• Molecular weight: 638.82