CAS 19396-06-6

Polyoxin B

Description:

Polyoxin B is a natural antifungal compound produced by the fermentation of certain Streptomyces species, particularly Streptomyces griseus. It is classified as a nucleoside antibiotic and is primarily known for its ability to inhibit the synthesis of chitin, a critical component of fungal cell walls. This mechanism of action makes Polyoxin B effective against a variety of fungal pathogens, particularly in agricultural settings where it is used as a biopesticide. The compound exhibits a broad spectrum of antifungal activity, targeting fungi such as Fusarium and Rhizoctonia species. Polyoxin B is characterized by its relatively low toxicity to mammals, which makes it a safer alternative to synthetic fungicides. Additionally, it is soluble in water, allowing for easy application in various formulations. Its use is particularly valued in organic farming due to its natural origin and minimal environmental impact. Overall, Polyoxin B represents an important tool in the management of fungal diseases in crops while promoting sustainable agricultural practices.

Formula: C₁₇H₂₅N₅O₁₃

InChI: InChI=1S/C17H25N5O13/c18-6(8(25)5(24)3-34-16(19)32)13(29)20-7(15(30)31)11-9(26)10(27)14(35-11)22-1-4(2-23)12(28)21-17(22)33/h1,5-11,14,23-27H,2-3,18H2,(H2,19,32)(H,20,29)(H,30,31)(H,21,28,33)/t5-,6-,7-,8+,9-,10+,11+,14+/m0/s1

InChI key: InChIKey=YFZNSPMAOIVQRP-YVKGXWRCSA-N

SMILES: O[C@H]1[C@@H](O[C@]([C@H](NC([C@H]([C@@H]([C@H](COC(N)=O)O)O)N)=O)C(O)=O)([C@H]1O)[H])N2C=C(CO)C(=O)NC2=O

Synonyms:

• (2S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}ethanoic acid (non-preferred name)
• (2S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{(2R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}ethanoic acid (non-preferred name)
• 5-(2-Amino-5-O-carbamoyl-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-beta-D-allofuranuronic acid
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-<span class="text-smallcaps">L</smallcap>-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-<smallcap>D</span>-allofuranuronic acid
• Allofuranuronic acid, 5-(2-amino-2-deoxy-<span class="text-smallcaps">L</smallcap>-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-, monocarbamate (ester), β-<smallcap>D</span>-
• Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-, monocarbamate (ester), beta-D-
• Duoyangqing
• Milpan
• Polar
• Polar (antibiotic)
• Polyoxin AL
• Polyoxin B
• Polyoxin B 34% Tk
• {[2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}acetic acid (non-preferred name)
• β-<span class="text-smallcaps">D</smallcap>-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-<smallcap>L</span>-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
• Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-, monocarbamate (ester), β-D-
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-D-allofuranuronic acid
• β-D-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
• 5-(2-amino-5-o-carbamoyl-2-deoxy-l-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1-(2h)-pyrimidinyl)-beta-d-allofuranuronicacid
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid
• 5-[[2-amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronicacid
• ro-5-(hydroxymethyl)-2,4-dioxo-1(2h)-pyrimidinyl)-,monocarbamate(ester),bet
• polyoxin AL(JMAF)
• polyoxinal
• 5-[(2-Amino-5-O-carbamoyl-2-deoxy-L-xylonoyl)amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid
• 5-[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylos-1-ylamino]-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
• 5-[[2-amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronic acid
• allofuranuronicacid,5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihyd
• 5-{[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl] amino}-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimnidinyl]-β-D-allofur-a-nuronic acid
• POLYXIN

b-D-Allofuranuronic acid,5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-

CAS: 19396-06-6

Formula: C₁₇H₂₅N₅O₁₃

Purity: 70%

Color and Shape: Solid

Molecular weight: 507.4061

Ref: IN-DA00I31H

Polyoxin b

CAS: 19396-06-6

Polyoxin b

Formula: C₁₇H₂₅N₅O₁₃

Purity: ≥95%

Color and Shape: solid

Molecular weight: 507.41g/mol

Ref: 54-OR927861

Polyoxin B

CAS: 19396-06-6

Polyoxin B

Purity: ≥70%

Molecular weight: 507.41g/mol

Ref: 54-BUP03267

Polyoxin B

CAS: 19396-06-6

Formula: C₁₇H₂₅N₅O₁₃

Molecular weight: 507.41

Ref: 4Z-P-288002

Polyoxin B

CAS: 19396-06-6

Polyoxin B is an antifungal peptidyl nucleoside antibiotic that inhibits fungal cell wall biosynthesis.

Formula: C₁₇H₂₅N₅O₁₃

Purity: 79.94%

Color and Shape: Solid

Molecular weight: 507.41

Ref: TM-T28436

Polyoxin B

CAS: 19396-06-6

Polyoxin B is a natural product that is produced by the fungus Polyporus umbellatus. It is a synthetase inhibitor that specifically inhibits the enzyme malic acid synthetase in bacteria and fungi. Polyoxin B has been shown to have antifungal activity in vitro and to inhibit the growth of Cryptococcus neoformans, which may be due to its ability to inhibit terminal residues, such as acetate extract, bacterial strain, and synthase enzyme.

Formula: C₁₇H₂₅N₅O₁₃

Purity: Min. 70%

Color and Shape: Yellow Powder

Molecular weight: 507.41 g/mol

Ref: 3D-NP140526