CAS 194159-18-7

Ganciclovir Monoproprionate

Description:

Ganciclovir Monoproprionate is a chemical compound derived from ganciclovir, an antiviral medication primarily used to treat cytomegalovirus (CMV) infections, particularly in immunocompromised patients. It is characterized by its structure, which includes a modified guanine base, contributing to its mechanism of action as a nucleoside analogue. The compound exhibits antiviral properties by inhibiting viral DNA synthesis, thereby preventing the replication of the virus. Ganciclovir Monoproprionate is typically presented as a white to off-white powder and is soluble in water, which facilitates its use in various pharmaceutical formulations. Its pharmacokinetics and bioavailability may differ from those of ganciclovir, potentially influencing its therapeutic efficacy and safety profile. As with many antiviral agents, it may have side effects, including hematological toxicity, and requires careful monitoring during treatment. Overall, Ganciclovir Monoproprionate represents a significant advancement in antiviral therapy, particularly for patients at risk of CMV-related complications.

Formula: C₁₂H₁₇N₅O₅

Synonyms:

• Valganciclovir USP RC J
• Ganciclovir Monoproprionate
• 2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3- hydroxypropyl propionate
• Ganciclovir EP Impurity B (Ganciclovir Monopropionate)
• valganciclovirhydrochloride iMpurit J
• Ganciclovir Impurity B
• Ganciclovir Impurity 9
• Ganciclovir Impurity 2(Ganciclovir EP Impurity B)
• Ganciclovir Mono-O-propionate
• Ganciclovir impurities817
• [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] propanoate
• Valganciclovir Hydrochloric iMpurit J
• 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[1-(hydroxymethyl)-2-(1-oxopropoxy)ethoxy]methyl]-
• Ganciclovir Monopropionate
• Ganciclovir EP impurity B

Ganciclovir EP Impurity B (Ganciclovir Monopropionate)

CAS: 194159-18-7

Formula: C₁₂H₁₇N₅O₅

Color and Shape: White To Off-White Solid

Molecular weight: 311.30

Ref: 4Z-G-163

2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl propionate

CAS: 194159-18-7

2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl propionate

Purity: 98%

Molecular weight: 311.3g/mol

Ref: 54-OR1067156

(2RS)-2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxy-propyl Propionate (Ganciclovir Monopropionate)

CAS: 194159-18-7

Color and Shape: Neat

Ref: 86-MM0485.03

Ganciclovir EP Impurity B

CAS: 194159-18-7

Formula: C₁₂H₁₇N₅O₅

Molecular weight: 311.30

Ref: ST-EA-CP-G5002

Ganciclovir Mono-O-propionate

CAS: 194159-18-7

Impurity Valganociclovir EP Impurity J
Applications Ganciclovir Mono-O-propionate is a potential prodrug of Ganciclovir (G235000). Ganciclovir Mono-O-propionate was also found to exhibit anti-viral activity through experimental studies.
References Dias, C.S., et al.: J. Pharma. Sci., 91, 660 (2002);

Formula: C₁₂H₁₇N₅O₅

Color and Shape: Neat

Molecular weight: 311.29

Ref: TR-G235020

Ganciclovir mono-o-propionate

CAS: 194159-18-7

Ganciclovir mono-o-propionate is an analytical reference standard for HPLC analysis. It is also a drug development intermediate, an API impurity, and a metabolite of ganciclovir. Ganciclovir mono-o-propionate is a crystalline solid with a melting point of 119°C and a molecular weight of 312.5. This compound can be found in the USP/NF (2009) as an impurity in the ganciclovir product. Ganciclovir mono-o-propionate has been used by companies to synthesize ganciclovir or other analogues for research purposes. The natural form of this compound can be found in plants such as apple leaves and grape leaves, but it can also be synthesized from chloroacetic acid and propionic acid.

Formula: C₁₂H₁₇N₅O₅

Purity: Min. 95%

Molecular weight: 311.29 g/mol

Ref: 3D-UHA15918