CAS 194413-58-6

Semaxanib

Description:

Semaxanib, also known by its chemical name, is a small molecule that functions primarily as an angiogenesis inhibitor. It is characterized by its ability to interfere with the formation of new blood vessels, which is a critical process in tumor growth and metastasis. Semaxanib acts by targeting specific pathways involved in angiogenesis, particularly those related to vascular endothelial growth factor (VEGF). This compound is often studied in the context of cancer therapy, as inhibiting angiogenesis can potentially limit tumor progression and improve treatment outcomes. In terms of its chemical structure, Semaxanib features a unique arrangement of functional groups that contribute to its biological activity. The compound is typically administered in a controlled manner to maximize its therapeutic effects while minimizing side effects. Research continues to explore its efficacy and safety profile in various cancer types, making it a subject of interest in oncology and pharmacology.

Formula: C₁₅H₁₄N₂O

InChI: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-

InChI key: InChIKey=WUWDLXZGHZSWQZ-WQLSENKSSA-N

SMILES: C(=C\1/C=2C(NC1=O)=CC=CC2)\C=3NC(C)=CC3C

Synonyms:

• (3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
• (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
• (Z)-3-(3,5-Dimethylpyrrol-2-ylmethylene)indolin-2-one
• (Z)-Su 5416
• 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-, (3Z)-
• 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-, (Z)-
• 3-((2,4-Dimethylpyrrol-5-YL)METHYLIDENYL)-2-indolonone
• 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene]-2-oxo-2,3-dihydroindole
• Nsc-696819
• Semaxanib
• Semoxind
• Su-5416
• Sugen

3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinon

CAS: 194413-58-6

Formula: C₁₅H₁₄N₂O

Purity: %

Color and Shape: Solid

Molecular weight: 238.2845

Ref: IN-DA00ACLO

(Z)-3-((3,5-Dimethyl-1H-Pyrrol-2-Yl)Methylene)Indolin-2-One

CAS: 194413-58-6

(Z)-3-((3,5-Dimethyl-1H-Pyrrol-2-Yl)Methylene)Indolin-2-One

Purity: 99+%

Molecular weight: 238.28g/mol

Ref: 54-OR1025424

(Z)-Semaxinib

CAS: 194413-58-6

(Z)-Semaxinib

Purity: ≥95%

Molecular weight: 238.28g/mol

Ref: 54-BUP15205

(Z)-Semaxinib

CAS: 194413-58-6

(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for

Formula: C₁₅H₁₄N₂O

Purity: 98.82% - ≥95%

Color and Shape: Solid

Molecular weight: 238.28

Ref: TM-T2496