CAS 194423-06-8

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide

Description:

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide is a chemical compound characterized by its complex structure, which includes a quinazoline core, an amine group, and a butynamide moiety. This compound features a brominated phenyl group, which can influence its biological activity and solubility. The quinazoline ring is known for its presence in various pharmacologically active compounds, often exhibiting properties such as anti-cancer and anti-inflammatory activities. The butynamide group contributes to the compound's reactivity and potential interactions in biological systems. Its molecular structure suggests that it may participate in hydrogen bonding and other intermolecular interactions, which are critical for its function in biological contexts. The presence of the bromine atom can also enhance lipophilicity, affecting the compound's absorption and distribution in biological systems. Overall, this compound's unique structural features make it a subject of interest in medicinal chemistry and drug development.

Formula: C₁₈H₁₃BrN₄O

InChI: InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)

InChI key: InChIKey=BTYYWOYVBXILOJ-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=CC(NC(C#CC)=O)=C2)N=CN1)C3=CC(Br)=CC=C3

Synonyms:

• N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
• 2-Butynamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
• EKI 785
• CL 387785
• WAY-EKI 785

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

CAS: 194423-06-8

Formula: C₁₈H₁₃BrN₄O

Purity: 97%

Color and Shape: Solid

Molecular weight: 381.2260

Ref: IN-DA00ABJJ

CL-387785

CAS: 194423-06-8

CL-387785

Purity: ≥95%

Molecular weight: 381.23g/mol

Ref: 54-BUP15479

CL-387785

CAS: 194423-06-8

Formula: C₁₈H₁₃BrN₄O

Purity: >98.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 381.23

Ref: 3B-C3575

CL-387785

CAS: 194423-06-8

CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.

Formula: C₁₈H₁₃BrN₄O

Purity: 99.56% - 99.62%

Color and Shape: Solid

Molecular weight: 381.23

Ref: TM-T2245

CL 387785

CAS: 194423-06-8

Irreversible inhibitor of EGFR receptor

Formula: C₁₈H₁₃BrN₄O

Purity: Min. 95%

Molecular weight: 381.23 g/mol

Ref: 3D-FC29856