CAS 194423-53-5

(3R,4β,7α)-7-(4-Chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-(4-hydroxyphenyl)-2-azaspiro[3.5]nonan-1-one

Description:

The chemical substance with the name "(3R,4β,7α)-7-(4-Chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-(4-hydroxyphenyl)-2-azaspiro[3.5]nonan-1-one" and CAS number "194423-53-5" is characterized by its complex spirocyclic structure, which includes multiple aromatic rings and functional groups. This compound features a spirocyclic framework that contributes to its unique three-dimensional conformation, potentially influencing its biological activity. The presence of hydroxyl groups indicates that it may exhibit hydrogen bonding capabilities, which can enhance solubility and reactivity. The chlorophenyl and fluorophenyl substituents suggest that the compound may possess significant lipophilicity, affecting its interaction with biological membranes. Additionally, the azaspiro structure may impart specific pharmacological properties, making it of interest in medicinal chemistry. Overall, this compound's intricate structure and functional groups suggest potential applications in drug development, particularly in targeting specific biological pathways or receptors. Further studies would be necessary to elucidate its precise biological activity and therapeutic potential.

Formula: C₂₆H₂₃ClFNO₃

InChI: InChI=1S/C26H23ClFNO3/c27-19-5-3-18(4-6-19)26(32)15-13-25(14-16-26)23(17-1-11-22(30)12-2-17)29(24(25)31)21-9-7-20(28)8-10-21/h1-12,23,30,32H,13-16H2/t23-,25-,26+/m1/s1

InChI key: InChIKey=DPZUDTYEZMUJDW-ARMFNRFLSA-N

SMILES: O=C1[C@@]2([C@H](N1C3=CC=C(F)C=C3)C4=CC=C(O)C=C4)CC[C@@](O)(CC2)C5=CC=C(Cl)C=C5

Synonyms:

• Sch 58053
• 2-Azaspiro[3.5]nonan-1-one, 7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-(4-hydroxyphenyl)-, (3R,4β,7α)-
• (3R,4β,7α)-7-(4-Chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-(4-hydroxyphenyl)-2-azaspiro[3.5]nonan-1-one
• 2-Azaspiro[3.5]nonan-1-one, 7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-(4-hydroxyphenyl)-, [4(R)-cis]-

Sch 58053-d4

Controlled Product

CAS: 194423-53-5

Applications A labelled analog of Ezetimibe (E975000). SCH 58053 is a potent, rapid, and selective inhibitor of lymphatic cholesterol transport in the intestine.
References Ly, H., et al.: Biochem. J., 286, 937 (1992), Dujovne, C., et al.: Am. J. Cardiol., 90, 1092 (2002), Repa, J., et al.: J. Lipid Res., 43, 1864 (2002), Knopp, R., et al.: Eur. Heart J., 24, 729 (2003), Altmann, S., et al.: Science, 303, 1201 (2004),

Formula: C₂₆H₁₉D₄ClFNO₃

Color and Shape: Neat

Molecular weight: 455.95

Ref: TR-S199952

Sch 58053

Controlled Product

CAS: 194423-53-5

Applications An analog of Ezetimibe (E975000). SCH 58053 is a potent, rapid, and selective inhibitor of lymphatic cholesterol transport in the intestine.
References Ly, H., et al.: Biochem. J., 286, 937 (1992), Dujovne, C., et al.: Am. J. Cardiol., 90, 1092 (2002), Repa, J., et al.: J. Lipid Res., 43, 1864 (2002), Knopp, R., et al.: Eur. Heart J., 24, 729 (2003), Altmann, S., et al.: Science, 303, 1201 (2004),

Formula: C₂₆H₂₃ClFNO₃

Color and Shape: Neat

Molecular weight: 451.92

Ref: TR-S199950

SCH 58053

CAS: 194423-53-5

Inhibitor of cholesterol absorption

Formula: C₂₆H₂₃ClFNO₃

Purity: Min. 95%

Molecular weight: 451.92 g/mol

Ref: 3D-FS27804

Sch 58053

CAS: 194423-53-5

Sch 58053 is an analog of Ezetimibe and a selective inhibitor of lymphatic cholesterol transport in the intestine.

Formula: C₂₆H₂₃ClFNO₃

Color and Shape: Solid

Molecular weight: 451.92

Ref: TM-T70048