CAS 194468-36-5
:Vinflunine ditartrate
Description:
Vinflunine ditartrate is a synthetic vinca alkaloid derivative primarily used in cancer treatment, particularly for advanced or metastatic transitional cell carcinoma of the bladder. It functions as a microtubule inhibitor, disrupting the normal function of the mitotic spindle during cell division, which ultimately leads to cell death. The compound is characterized by its ability to bind to tubulin, preventing its polymerization into microtubules, thereby inhibiting mitosis. Vinflunine is typically administered intravenously and has a specific pharmacokinetic profile, including a moderate half-life and metabolism primarily through the liver. Its side effects may include neutropenia, constipation, and fatigue, which are common among chemotherapeutic agents. The ditartrate form enhances its solubility and stability, facilitating its formulation for clinical use. As with many anticancer drugs, careful monitoring of patient response and side effects is essential during treatment. Overall, vinflunine represents a targeted approach in oncology, contributing to the arsenal of therapies available for managing specific types of cancer.
Formula:C45H54F2N4O8·2C4H6O6
InChI:InChI=1S/C45H54F2N4O8.C4H6O6/c1-8-42-14-11-16-51-17-15-43(36(42)51)30-19-31(34(56-5)20-33(30)49(4)37(43)45(55,40(54)58-7)38(42)59-25(2)52)44(39(53)57-6)21-26-18-27(41(3,46)47)23-50(22-26)24-29-28-12-9-10-13-32(28)48-35(29)44;5-1(3(7)8)2(6)4(9)10/h9-14,19-20,26-27,36-38,48,55H,8,15-18,21-24H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t26-,27+,36-,37+,38+,42+,43+,44-,45-;1-,2-/m01/s1
InChI key:InChIKey=TXONSEMUKVZUON-MSNAZLETSA-N
SMILES:C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C[C@@H](C(C)(F)F)C9)[H])[H])CCN3CC=C2)[H].[C@@H]([C@H](C(O)=O)O)(C(O)=O)O
Synonyms:- 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate
- 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2)
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
- Bms 710485
- Javlor
- Vinflunine Ditartrate
- F 12158
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Found 4 products.
Vinflunine ditartrate
CAS:Vinflunine ditartrate: a fluorinated Vinca alkaloid, anti-angiogenic, disrupts vessels, anti-metastatic, used in certain cancer studies.Formula:C49H60F2N4O14Color and Shape:SolidMolecular weight:967.03Vinflunine ditartrate
CAS:Vinflunine ditartrate is a chemotherapeutic agent, specifically a bi-fluorinated vinca alkaloid derivative. It is synthesized from natural alkaloids found in the Madagascar periwinkle plant (Catharanthus roseus), which are known for their potent antineoplastic properties. Vinflunine acts by targeting tubulin, a structural protein crucial for the formation of microtubules in cells. It disrupts the polymerization of tubulin, leading to cell cycle arrest at the metaphase, ultimately inducing apoptosis in rapidly dividing cancer cells.Formula:C53H66F2N4O20Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:1,117.1 g/mol
