CAS 194798-83-9

Fosfluconazole

Description:

Fosfluconazole is an antifungal agent belonging to the triazole class, primarily used in the treatment of fungal infections. It is a prodrug of fluconazole, meaning it is converted into its active form in the body. The substance exhibits broad-spectrum antifungal activity, particularly against Candida species and Cryptococcus neoformans. Fosfluconazole is characterized by its high oral bioavailability and favorable pharmacokinetic profile, allowing for effective systemic treatment. It is typically administered in a phosphate form, which enhances its solubility and absorption. The mechanism of action involves the inhibition of fungal cytochrome P450 enzymes, specifically 14α-demethylase, which is crucial for ergosterol synthesis, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately cell death. Fosfluconazole is generally well-tolerated, with a side effect profile similar to that of fluconazole, including potential gastrointestinal disturbances and liver enzyme elevations. Its development represents a significant advancement in antifungal therapy, particularly for patients with compromised immune systems.

Formula: C₁₃H₁₃F₂N₆O₄P

InChI: InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)

InChI key: InChIKey=GHJWNRRCRIGGIO-UHFFFAOYSA-N

SMILES: C(CN1C=NC=N1)(CN2C=NC=N2)(OP(=O)(O)O)C3=C(F)C=C(F)C=C3

Synonyms:

• 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-((1H-1,2,4-triazol-1-yl)methyl)ethyl dihydrogen phosphate
• 1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-, 1-(dihydrogen phosphate)
• 1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-, dihydrogen phosphate (ester)
• 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol, dihydrogen phosphate (ester)
• 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-yl dihydrogen phosphate
• Procif
• Prodif
• Uk-292,663
• Unii-3Jij299Ewh
• Fosfluconazole

Fosfluconazole

CAS: 194798-83-9

Formula: C₁₃H₁₃F₂N₆O₄P

Purity: %

Molecular weight: 386.2507

Ref: IN-DA00ABTV

Fosfluconazole

CAS: 194798-83-9

Fosfluconazole

Purity: ≥98%

Molecular weight: 386.25g/mol

Ref: 54-BUP10263

Fosfluconazole

CAS: 194798-83-9

Formula: C₁₃H₁₃F₂N₆O₄P

Color and Shape: White To Off-White Solid

Molecular weight: 386.26

Ref: 4Z-F-1417

Fosfluconazole

CAS: 194798-83-9

Fosfluconazole is water-soluble phosphate prodrug of fluconazole. Fluconazole is an antifungal drug.

Formula: C₁₃H₁₃F₂N₆O₄P

Purity: 99.12%

Color and Shape: Solid

Molecular weight: 386.25

Ref: TM-T5328