CAS 194804-75-6: Garenoxacin

Description: Garenoxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against Gram-positive and Gram-negative bacteria. It is primarily used in the treatment of respiratory tract infections, including pneumonia and bronchitis, due to its ability to inhibit bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. Garenoxacin exhibits a favorable pharmacokinetic profile, with good oral bioavailability and tissue penetration, which enhances its therapeutic efficacy. The compound is known for its relatively low propensity to induce resistance compared to other antibiotics in its class. Additionally, Garenoxacin has been studied for its potential effectiveness against certain atypical pathogens and has shown promise in treating infections caused by resistant strains. Its safety profile includes common antibiotic-related side effects, but it is generally well-tolerated. As with all antibiotics, appropriate use is essential to minimize the risk of developing antibiotic resistance.

Formula: C₂₃H₂₀F₂N₂O₄

InChI: InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1

InChI key: InChIKey=NJDRXTDGYFKORP-LLVKDONJSA-N

SMILES: O=C(O)C1=CN(C=2C(OC(F)F)=C(C=CC2C1=O)C3=CC=C4C(=C3)CNC4C)C5CC5

Synonyms:

• (R)-1-Cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methanesulfonate (1:1)
• 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-7-(2,3-dihydro-1-methyl-1H-isoindol-5-yl)-1,4-dihydro-4-oxo-, (+)-
• 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-
• Ganefloxacin
• Garenfloxacin
• Garenoxacin Hbr
• T 3811
• Garenoxacin

Garenoxacin

CAS: 194804-75-6

Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative …

• Formula: C₂₃H₂₀F₂N₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 426.41

Garenoxacin

CAS: 194804-75-6

Please enquire for more information about Garenoxacin including the price, delivery time and more detailed …

• Formula: C₂₃H₂₀F₂N₂O₄
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 426.41 g/mol

Garenoxacin

CAS: 194804-75-6

Stability Hygroscopic Applications Des-F(6)-quinolone antibacterial; topoisomerase II inhibitor. Antibacterial. References Hayashi, K., et al.: Arzneim.-Forsch., …

• Formula: C₂₃H₂₀F₂N₂O₄
• Color and Shape: Off White Solid
• Molecular weight: 426.41