CAS 1948273-02-6

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

Description:

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-, identified by CAS number 1948273-02-6, is a synthetic organic compound that belongs to the class of amino acids and their derivatives. This compound features a prolinamide backbone, which is characterized by the presence of a proline-derived structure with an amide functional group. The molecule exhibits chirality, indicated by the (4R) configuration, which can influence its biological activity and interactions. The presence of a thiazole ring and a phenyl group suggests potential applications in medicinal chemistry, particularly in drug design, due to their roles in enhancing pharmacological properties. Additionally, the hydroxyl group contributes to the compound's polarity and solubility characteristics. Overall, L-Prolinamide is of interest in research contexts, particularly in studies related to peptide synthesis, biological activity, and structure-activity relationships in pharmaceutical development.

Formula: C₂₃H₃₂N₄O₃S

InChI: InChI=1S/C23H32N4O3S/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29)/t13-,17+,18-,20+/m0/s1

InChI key: InChIKey=JOSFQWNOUSNZBP-UUZHKXTQSA-N

SMILES: C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Synonyms:

• L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
• (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• (2S,4R)-1-((2S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-N-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide

CAS: 1948273-02-6

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-N-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide

Purity: 97%,99.9%ee

Molecular weight: 444.59g/mol

Ref: 54-OR1008034

(S,R,S)-AHPC-Me

CAS: 1948273-02-6

(S,R,S)-AHPC-Me

Purity: ≥98%

Molecular weight: 444.59g/mol

Ref: 54-BUP11367

(S,R,S)-AHPC-Me

CAS: 1948273-02-6

(S,R,S)-AHPC-Me is a VHL ligand for synthesizing the BET degrader ARV-771, which targets CRPC cells.

Formula: C₂₃H₃₂N₄O₃S

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 444.59

Ref: TM-T7752

(S,R,S)-AHPC-Me

CAS: 1948273-02-6

Purity: 98%

Molecular weight: 444.59

Ref: 10-F981811

E3 Ligase ligand 1a

CAS: 1948273-02-6

E3 Ligase Ligand 1a is a small molecule ligand, which is typically synthesized in a laboratory setting. The ligand acts as a recruiter for E3 ubiquitin ligases, proteins that play a pivotal role in the ubiquitin-proteasome pathway. By binding to an E3 ligase, the ligand can facilitate the ubiquitination and subsequent degradation of target proteins. This mechanism is central to modulating protein levels within a cell, enabling researchers to study protein function and regulation dynamically.

Formula: C₂₃H₃₂N₄O₃S

Purity: Min. 95%

Molecular weight: 444.6 g/mol

Ref: 3D-YCD27302