CAS 1948273-03-7

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, hydrochloride (1:1), (4R)-

Description:

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, hydrochloride (1:1), with CAS number 1948273-03-7, is a synthetic compound that belongs to the class of amino acid derivatives. This substance features a complex structure characterized by the presence of a proline derivative, a thiazole moiety, and a phenyl group, which contribute to its potential biological activity. The hydrochloride form indicates that it is a salt, enhancing its solubility in aqueous solutions, which is often beneficial for pharmacological applications. The compound may exhibit specific stereochemistry, as indicated by the (1S) and (4R) designations, which can influence its interaction with biological targets. Its unique combination of functional groups suggests potential uses in medicinal chemistry, particularly in the development of pharmaceuticals. However, detailed studies on its pharmacodynamics, pharmacokinetics, and toxicity would be necessary to fully understand its properties and potential applications.

Formula: C₂₃H₃₂N₄O₃S·ClH

InChI: InChI=1S/C23H32N4O3S.ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5;/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29);1H/t13-,17+,18-,20+;/m0./s1

InChI key: InChIKey=GHFOLQCCYGBOTL-QDVBFIRISA-N

SMILES: C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl

Synonyms:

• (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride
• (2S,4R)-1-((2S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide monohydrochloride
• L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, hydrochloride (1:1), (4R)-
• (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride
• (2S,4R)-1-((2S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride

(S,R,S)-AHPC-Me hydrochloride

CAS: 1948273-03-7

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein

Formula: C₂₃H₃₃ClN₄O₃S

Purity: 99.18%

Color and Shape: Solid

Molecular weight: 481.05

Ref: TM-T13671

(S,R,S)-AHPC-Me hydrochloride

CAS: 1948273-03-7

(S,R,S)-AHPC-Me hydrochloride

Purity: ≥98%

Molecular weight: 481.05g/mol

Ref: 54-BUP14166

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-N-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride

CAS: 1948273-03-7

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-N-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride

Purity: 98%

Molecular weight: 481.05g/mol

Ref: 54-OR1029403

(S,R,S)-AHPC-Me hydrochloride

CAS: 1948273-03-7

Purity: 96%

Molecular weight: 480.2

Ref: 10-F554450

E3 ligase Ligand 1

CAS: 1948273-03-7

E3 ligase Ligand 1 is a ligand that is used to monitor e3 ligases in the laboratory. It is a protein with a molecular weight of approximately 40 kDa and contains a cysteine residue at its N-terminus. The fluorescein moiety is covalently attached to the lysine side chain of the cysteine residue. This fluorescent molecule can be photoactivated by irradiation with light in order to induce proteolysis and release the fluorescent product, which can then be monitored by fluorescence microscopy. E3 ligase Ligand 1 has been shown to degrader proteins in vitro, as well as being able to trigger photocaging reactions and cause photoactivation of fluorophores.

Formula: C₂₃H₃₃ClN₄O₃S

Purity: Min. 95%

Molecular weight: 481.1 g/mol

Ref: 3D-FE178607