CAS 1949-20-8

Oxolamine citrate

Description:

Oxolamine citrate, with the CAS number 1949-20-8, is a chemical compound that serves primarily as an antihistamine and antitussive agent. It is characterized by its ability to alleviate cough and relieve symptoms associated with allergies and colds. The compound is typically found in the form of a citrate salt, which enhances its solubility and bioavailability. Oxolamine citrate exhibits a moderate safety profile, making it suitable for use in various pharmaceutical formulations. Its mechanism of action involves the inhibition of histamine receptors, thereby reducing the physiological effects of histamine, such as bronchoconstriction and increased mucus production. Additionally, it may possess mild sedative properties, which can be beneficial in treating coughs associated with colds or allergies. As with many medications, potential side effects may include drowsiness, dry mouth, or gastrointestinal disturbances. Overall, oxolamine citrate is valued for its therapeutic applications in respiratory conditions, contributing to symptomatic relief in patients.

Formula: C₁₄H₁₉N₃O·C₆H₈O₇

InChI: InChI=1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key: InChIKey=RBZIGQJSMCOHSS-UHFFFAOYSA-N

SMILES: C(CN(CC)CC)C1=NC(=NO1)C2=CC=CC=C2.C(CC(O)=O)(CC(O)=O)(C(O)=O)O

Synonyms:

• 1,2,4-Oxadiazole, 5-[2-(diethylamino)ethyl]-3-phenyl-, citrate (1:1)
• 1,2,4-Oxadiazole-5-ethanamine, N,N-diethyl-3-phenyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• 3-Phenyl-5-(diethylaminoethyl)-1,2,4-oxadiazole citrate
• 5-(Diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole citrate
• 5-[2-(Diethylamino)Ethyl]-3-Phenyl-1,2,4-Oxadiazole Citrate Salt
• Af 438
• Bredon
• Broncatar
• Flogobron
• N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanaminium 3,4-dicarboxy-3-hydroxybutanoate
• NSC 100298
• Oxarmin
• Oxolamine Dihydrogen Citrate
• Perebron
• Prilon

Oxolamine citrate

CAS: 1949-20-8

Oxolamine citrate (AF-438 citrate) is a cough suppressant that is able to be used as a generic drug in many jurisdictions.

Formula: C₁₄H₁₉N₃O·C₆H₈O₇

Purity: 99.76%

Color and Shape: White Or Off-White Crystalline Powder

Molecular weight: 437.44

Ref: TM-T0768

Oxolamine citrate

CAS: 1949-20-8

Oxolamine citrate

Purity: ≥98%

Molecular weight: 437.44g/mol

Ref: 54-BUP19359

Oxolamine Citrate

CAS: 1949-20-8

Formula: C₁₄H₁₉N₃O·C₆H₈O₇

Color and Shape: White To Off-White Solid

Molecular weight: 245.33 192.13

Ref: 4Z-O-041001

Oxolamine Citrate

CAS: 1949-20-8

Applications Oxolamine Citrate, is a antiinflammatory drug used as a cough suppressant.
References Zhu, X.. et al.: Biopharma. Drug. Disp., 28, 125 (2007); Yuen, T., et al.: Biochem. Biophy. Res. Comm., 422, 573 (2012);

Formula: C₁₄H₁₉N₃O·C₆H₈O₇

Color and Shape: Neat

Molecular weight: 437.44

Ref: TR-O857450

Oxolamine citrate salt

CAS: 1949-20-8

Oxolamine citrate salt is a pharmaceutical drug used for the treatment of scleroderma. It acts as an iron chelator and inhibits the production of the cytotoxic agent, podophyllotoxin, by inhibiting its conversion to epipodophyllotoxin. Oxolamine citrate salt has been shown to have a beneficial effect on Alzheimer's disease and may have therapeutic potential in other neurological diseases such as Parkinson's disease. The compound has been shown to inhibit acetonitrile-induced hyperactivity in mice. Oxolamine citrate salt has also been found to be effective against Pseudomonas aeruginosa and Staphylococcus aureus isolates that are resistant to oxacillin, ginkgetin, or pseudoephedrine. This drug can be analyzed using liquid chromatography with an acetonitrile gradient and a hypersil C18 column.

Formula: C₁₄H₁₉N₃O·C₆H₈O₇

Purity: Min. 95%

Molecular weight: 437.44 g/mol

Ref: 3D-BAA94920

Oxolamine Citrate

CAS: 1949-20-8

Formula: C₁₄H₁₉N₃OC₆H₈O₇

Molecular weight: 245.33 : 192.1

Ref: ST-EA-CP-O62001

Oxolamine citrate salt

CAS: 1949-20-8

Formula: C₂₀H₂₇N₃O₈

Color and Shape: Solid

Molecular weight: 437.4437

Ref: IN-DA003TIU