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CAS 194935-38-1

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Prostaglandin E2 ethanolamide

Description:
Prostaglandin E2 ethanolamide, also known as PGE2 ethanolamide, is a bioactive lipid compound derived from prostaglandin E2 (PGE2) through the amide formation with ethanolamine. This substance is characterized by its role in various physiological processes, including inflammation, pain modulation, and regulation of immune responses. It exhibits a range of biological activities, acting on specific receptors such as EP receptors, which are involved in mediating its effects on smooth muscle contraction, vasodilation, and neurotransmission. The compound is typically studied for its potential therapeutic applications, particularly in pain management and inflammatory conditions. Its structure includes a cyclopentane ring and multiple functional groups that contribute to its reactivity and interaction with biological systems. Additionally, PGE2 ethanolamide is of interest in research related to endocannabinoid signaling pathways, as it may influence cannabinoid receptor activity. Overall, this compound represents a significant area of study in pharmacology and biochemistry due to its complex roles in human health and disease.
Formula:C22H37NO5
InChI:InChI=1S/C22H37NO5/c1-2-3-6-9-17(25)12-13-19-18(20(26)16-21(19)27)10-7-4-5-8-11-22(28)23-14-15-24/h4,7,12-13,17-19,21,24-25,27H,2-3,5-6,8-11,14-16H2,1H3,(H,23,28)/b7-4-,13-12+/t17-,18+,19+,21+/m0/s1
InChI key:InChIKey=GKKWUSPPIQURFM-IGDGGSTLSA-N
SMILES:C(=C/[C@H](CCCCC)O)\[C@@H]1[C@@H](C/C=C\CCCC(NCCO)=O)C(=O)C[C@H]1O
Synonyms:
  • (5Z,11α,13E,15S)-11,15-Dihydroxy-N-(2-hydroxyethyl)-9-oxoprosta-5,13-dien-1-amide
  • N-(2-Hydroxyethyl)-9-Oxo-11Alpha,15S-Dihydroxy-Prosta-5Z,13E-Dien-1-Amide
  • PGE<sub>2</sub> ethanolamide
  • Pge2-Ea
  • Prosta-5,13-dien-1-amide, 11,15-dihydroxy-N-(2-hydroxyethyl)-9-oxo-, (5Z,11α,13E,15S)-
  • Prostaglandin E2 Ethanolamide
  • Prostaglandin E<sub>2</sub> ethanolamide
  • Prostamide E<sub>2</sub>
  • Prostamide E2
  • PGE2 ethanolamide
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  • Prostaglandin E2 Ethanolamide
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    Prostaglandin E2 Ethanolamide

    CAS:
    Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].
    Formula:C22H37NO5
    Color and Shape:Solid
    Molecular weight:395.54

    Ref: TM-T84584

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