CAS 1949802-49-6

PI3K/mTOR Inhibitor-1

Description:

PI3K/mTOR Inhibitor-1, identified by its CAS number 1949802-49-6, is a chemical compound that functions as an inhibitor of the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathways. These pathways are crucial for regulating cell growth, proliferation, and survival, making this compound of significant interest in cancer research and therapeutic development. The inhibitor is characterized by its ability to selectively target specific isoforms of PI3K and mTOR, which may lead to reduced tumor growth and enhanced apoptosis in cancer cells. Its chemical structure typically includes functional groups that facilitate binding to the active sites of the target enzymes, thereby blocking their activity. Additionally, studies have indicated that PI3K/mTOR Inhibitor-1 may exhibit varying degrees of efficacy depending on the cellular context and the presence of specific mutations in cancer cells. As with many pharmacological agents, understanding its pharmacokinetics, bioavailability, and potential side effects is essential for its application in clinical settings.

Formula: C₁₈H₂₂FN₅O₃S

Synonyms:

• PI3K/mTOR Inhibitor-1
• PI3K/mTOR Inhibitor1,PI-3K/mTOR Inhibitor-1,PI3K/mTOR Inhibitor 1
• 2-Pyridinamine, 4-fluoro-5-[2-[(3S)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-4-pyrimidinyl]-

PI3K/mTOR inhibitor-1

CAS: 1949802-49-6

PI3K/mTOR inhibitor-1 is a potent dual inhibitor targeting the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators in controlling cell growth, proliferation, and survival, originating from complex intracellular signaling cascades. PI3K/mTOR inhibitor-1 exerts its mechanism of action by competitively binding to the ATP-binding site of both PI3K and mTOR kinases, effectively hindering their catalytic activities. This blockade disrupts downstream signaling, leading to the inhibition of tumor cell proliferation and induction of apoptosis.

Formula: C₁₈H₂₂FN₅O₃S

Purity: Min. 95%

Molecular weight: 407.5 g/mol

Ref: 3D-ZCD80249

PI3K/mTOR Inhibitor-1

CAS: 1949802-49-6

PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)

Formula: C₁₈H₂₂FN₅O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 407.46

Ref: TM-T12460