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CAS 1953-04-4

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Galantamine hydrobromide

Description:
Galantamine hydrobromide is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the treatment of mild to moderate Alzheimer's disease and other cognitive disorders. It is a quaternary ammonium compound derived from the snowdrop plant and exhibits a dual mechanism of action by enhancing cholinergic function and modulating nicotinic receptors. The substance appears as a white to off-white crystalline powder, is soluble in water, and has a molecular formula that reflects its complex structure. Galantamine hydrobromide is typically administered orally and is known for its ability to improve cognitive function and memory in patients. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are influenced by factors such as age and liver function. Common side effects may include nausea, vomiting, and diarrhea, which are generally mild. As with any medication, it is essential to use galantamine hydrobromide under medical supervision to monitor for efficacy and potential adverse reactions.
Formula:C17H22BrNO3
InChI:InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/p+1/t12-,14-,17-/m0/s1
InChI key:InChIKey=QORVDGQLPPAFRS-XPSHAMGMSA-N
SMILES:O(C)C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C)CC3C=C1.Br
Synonyms:
  • (4aS,6R,8aS)-6-hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
  • 5A,6,7,8,8A,12B-Hexahydrogalanthamine Hydrobromide (1:1)
  • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide (1:1), (4aS,6R,8aS)-
  • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide, (4aS,6R,8aS)-
  • Galantamine Hbr
  • Galantamine Hydrobromide
  • Galanthamine HBr
  • Galanthamine Hydrobromide (1:1)
  • Galanthamine hydrogen bromide
  • Jilkon hydrobromide
  • See more synonyms
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