CAS 1953-04-4

Galantamine hydrobromide

Description:

Galantamine hydrobromide is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the treatment of mild to moderate Alzheimer's disease and other cognitive disorders. It is a quaternary ammonium compound derived from the snowdrop plant and exhibits a dual mechanism of action by enhancing cholinergic function and modulating nicotinic receptors. The substance appears as a white to off-white crystalline powder, is soluble in water, and has a molecular formula that reflects its complex structure. Galantamine hydrobromide is typically administered orally and is known for its ability to improve cognitive function and memory in patients. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are influenced by factors such as age and liver function. Common side effects may include nausea, vomiting, and diarrhea, which are generally mild. As with any medication, it is essential to use galantamine hydrobromide under medical supervision to monitor for efficacy and potential adverse reactions.

Formula: C₁₇H₂₂BrNO₃

InChI: InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/p+1/t12-,14-,17-/m0/s1

InChI key: InChIKey=QORVDGQLPPAFRS-XPSHAMGMSA-N

SMILES: O(C)C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C)CC3C=C1.Br

Synonyms:

• (4aS,6R,8aS)-6-hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
• 5A,6,7,8,8A,12B-Hexahydrogalanthamine Hydrobromide (1:1)
• 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide (1:1), (4aS,6R,8aS)-
• 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide, (4aS,6R,8aS)-
• Galantamine Hbr
• Galantamine Hydrobromide
• Galanthamine HBr
• Galanthamine Hydrobromide (1:1)
• Galanthamine hydrogen bromide
• Jilkon hydrobromide
• Lycoremine hydrobromide
• Nivalin
• Nivaline
• Nivaline (pharmaceutical)
• Razadyne
• Reminyl
• Tamilin
• Galanthamine, hydrobromide
• GALANTHAMINE HYDROBROMIDUM
• Galanthamine Hydrobromide Injection
• Hydrobromic acid·galanthamine
• 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE
• NIVALIN, HBR
• (-)-Galanthaminium bromide
• GALANTHAMIDE HYDROBROMIDE
• galanthamine hydrobromide from lycoris sp.

Galanthamine hydrobromide

Controlled Product

CAS: 1953-04-4

A reversible and competitive inhibitor of acetylcholinesterase (AChE) that is approved for the treatment of Alzheimer’s disease. It is also an allosteric modulator of nicotinic acetylcholine receptors (nAChR). Activation of nAChR along with upregulation of anti-apoptotic protein Bcl-2 prevents apoptosis and therefore provides neuroprotection.

Formula: C₁₇H₂₁NO₃·HBr

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 368.27 g/mol

Ref: 3D-FH15701

Galanthamine-O-methyl-d3 Hydrobromide

Controlled Product

CAS: 1953-04-4

Formula: C₁₇D₃H₁₈NO₃·HBr

Color and Shape: Neat

Molecular weight: 371.284

Ref: TR-G188504

9-Bromo-7-methoxy-1,2,3,4-tetrahydrobenzofuro[4,3-cd]azepine Hydrobromide

Controlled Product

CAS: 1953-04-4

Formula: C₁₂H₁₂BrNO₂·HBr

Color and Shape: Neat

Molecular weight: 363.05

Ref: TR-B188550

Galantamine Hydrobromide

CAS: 1953-04-4

Formula: C₁₇H₂₁NO₃HBr

Molecular weight: 287.4 : 80.9

Ref: ST-EA-CP-G10000

Galantamine Hydrobromide extrapure, 98%

CAS: 1953-04-4

Formula: C₁₇H₂₁NO₃·HBr

Purity: min. 98%

Color and Shape: White to off - white, Hygroscopic crystalline powder

Molecular weight: 368.27

Ref: SR-83055