CAS 1953146-83-2

Tri-GalNAc-NHS ester

CAS: 1953146-83-2

Tri-GalNAc-NHS ester, a LYsosome TArgeting Chimera (LYTAC) and ligand for the asialoglycoprotein receptor (ASGPR), facilitates the degradation of extracellular

Formula: C₇₉H₁₃₇N₁₁O₃₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 1832.98

Ref: TM-T80946

Tri-b-GalNAc-PEG5-NHS ester

CAS: 1953146-83-2

Tri-GalNAc-NHS ester is a multivalent molecule composed of three GalNAc cluster arms. It is a protein degrader and a ligand of the asialoglycoprotein receptor (ASGPR) used for the development of targeted therapies for liver diseases. The GalNAc arms enable high-affinity binding to the ASGPR on hepatocyte surfaces. The crucial functional group, N-hydroxysuccinimide (NHS) ester, is known for its ease of conjugation with various biomolecules possessing amine (NH2) groups. This biocompatible reaction strategy allows the design and development of targeted conjugates such as drug-GalNAc conjugates, siRNA delivery vehicles, or probes for ASGPR imaging in the liver.

Formula: C₇₉H₁₃₇N₁₁O₃₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,832.99 g/mol

Ref: 3D-FT183733