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CAS 19553-76-5

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disialoganglioside G(D1B) from bovine brain

Description:
Disialoganglioside G (D1B) is a complex glycosphingolipid predominantly found in the bovine brain, characterized by its unique structure that includes two sialic acid residues. This ganglioside plays a crucial role in cell-cell recognition, signaling, and membrane stability within the nervous system. Its structure consists of a ceramide backbone linked to a carbohydrate chain, which includes the sialic acid moieties that contribute to its negative charge and influence its interactions with other biomolecules. D1B is involved in various biological processes, including neuronal development and synaptic plasticity, and has been studied for its potential implications in neurodegenerative diseases. The presence of disialogangliosides like D1B is significant in the context of brain function and pathology, as they are implicated in modulating receptor activity and protecting neurons from oxidative stress. Overall, D1B exemplifies the intricate role of gangliosides in neurobiology and their potential as therapeutic targets in neurological disorders.
Formula:C84H148N4O40
InChI:InChI=1/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1
Synonyms:
  • (2R,4S,5R,6R)-2-[(2R,3S,4S,5R,6S)-5-[(2R,3S,4S,5S,6S)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-2-hydroxy-1-[(octadecanoylamino)methyl]heptadec-3-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-6-[3-[(2R,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-propyl]-4-hydroxy-tetrahydropyran-2-carboxylic acid
  • G<sub>D1b</sub>
  • GD1b ganglioside
  • Ganglioside C<sub>1</sub>
  • Ganglioside G<sub>2</sub>
  • Ganglioside G<sub>2</sub> (hexasaccharide)
  • Ganglioside G<sub>D1b</sub>
  • Ganglioside G<sub>III</sub>
  • Ganglioside GD1b, Disialo, Diammonium Salt, Bovine Brain
  • Ganglioside C1
  • See more synonyms
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Found 6 products.
  • CymitQuimica logo
    Targetmol
    + Info

    Ganglioside GD1b Mixture (sodium salt)

    CAS:
    <p>GD1b: acidic glycosphingolipid with two sialic acids linked to galactose, in plasma membranes, modulates cell signaling, increasing brain levels with age.</p>
    Formula:C84H146N4O392Na
    Color and Shape:Solid
    Molecular weight:1882.1

    Ref: TM-T36861

  • CymitQuimica logo
    Larodan
    + Info

    Disialoganglioside GD1b (NH4-salt)

    CAS:
    Formula:Unspecified
    Purity:>98%
    Color and Shape:Solid

    Ref: 48-56-1104

    1mg
    468.00€
  • GD1b-Ganglioside
    Glentham
    + Info

    GD1b-Ganglioside

    CAS:
    Formula:C84H146N4O39·2Na
    Purity:≥ 98.0%
    Color and Shape:White to yellow powder
    Molecular weight:1836.1 . 46.0

    Ref: 7W-GC0141

    1mg
    259.00€
  • GD1b-ganglioside sodium
    Biosynth
    + Info

    GD1b-ganglioside sodium

    CAS:
    <p>GD1b (shown as sodium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with it’s two sialic acids linked α2,3/α2,8 to the inner galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD1b acts as a receptor for BK virus as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012).</p>
    Purity:Min. 95%
    Color and Shape:Powder

    Ref: 3D-OG03920

    1mg
    264.00€
    2mg
    470.00€
  • GD1b-Ganglioside ammonium
    Biosynth
    + Info

    GD1b-Ganglioside ammonium

    CAS:
    <p>GD1b ganglioside (shown as ammonium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with its two sialic acids linked α2,3/α2,8 to the inner galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD1b ganglioside acts as a receptor for BK virus, as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012). The functional significance of ammonia in the brain is not yet fully understood: see (Modi 1994).</p>
    Purity:Min. 95%

    Ref: 3D-OG175968

    1mg
    554.00€
    2mg
    1,023.00€
    5mg
    2,257.00€
  • Ganglioside GD1b Disodium Salt (Bovine Brain)
    Indagoo
    + Info

    Ganglioside GD1b Disodium Salt (Bovine Brain)

    CAS:
    Formula:C50H81N2O24
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1094.1771

    Ref: IN-DA00AOEN

    1mg
    Discontinued
    Discontinued product