CAS 1956426-56-4

KN93 hydrochloride

Description:

KN93 hydrochloride is a chemical compound that serves primarily as a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). It is often utilized in biochemical research to study the role of CaMKII in various cellular processes, including signal transduction, muscle contraction, and neuronal function. The compound is characterized by its ability to bind to the calmodulin-binding site of CaMKII, thereby preventing its activation by calcium ions. This inhibition can lead to significant effects on cellular signaling pathways, making KN93 hydrochloride a valuable tool in pharmacological studies. The compound is typically presented as a hydrochloride salt, which enhances its solubility in aqueous solutions, facilitating its use in laboratory experiments. Additionally, KN93 hydrochloride is often used in studies related to cardiovascular health, neurobiology, and other fields where CaMKII plays a critical role. As with many research chemicals, proper handling and safety precautions are essential when working with KN93 hydrochloride in a laboratory setting.

Formula: C₂₆H₃₀Cl₂N₂O₄S

Synonyms:

• KN-93 (hydrochloride)
• CS-1449
• KN93 hydrochloride
• KN 93 hydrochloride
• KN-93 HCl

N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride

CAS: 1956426-56-4

N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride

Purity: 98%

Molecular weight: 537.51g/mol

Ref: 54-OR1074054

KN-93 hydrochloride

CAS: 1956426-56-4

KN-93 hydrochloride is a reversible, competitive CaMKII inhibitor inducing reversible G1 arrest, supporting cell cycle and signaling pathway studies.

Formula: C₂₆H₃₀Cl₂N₂O₄S

Purity: 99.99%

Color and Shape: Solid

Molecular weight: 537.5

Ref: TM-T21557

KN-93 hydrochloride

CAS: 1956426-56-4

KN-93 is a calcium channel blocker that has been shown to reduce the severity of arrhythmias in women with heart disease. KN-93 has also been shown to inhibit the development of cardiac arrhythmias during reperfusion and ventricular pressure, as well as modulate the activity of enzymes involved in the production of reactive oxygen species. KN-93 is a potent inhibitor of the L-type calcium channels, which are responsible for maintaining a constant intracellular calcium concentration. The inhibition causes an increase in the duration and amplitude of action potentials, leading to an increase in cardiac contractility. This drug has been shown to be effective as both a prophylactic agent and treatment for arrhythmias.

Formula: C₂₆H₃₀Cl₂N₂O₄S

Purity: Min. 95%

Molecular weight: 537.5 g/mol

Ref: 3D-GDD42656