CAS 195875-84-4

Tesofensine

Description:

Tesofensine is a chemical compound that functions primarily as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It was originally developed for the treatment of neurodegenerative diseases but has gained attention for its potential use in weight management and obesity treatment. Tesofensine is characterized by its ability to modulate neurotransmitter levels, which can lead to appetite suppression and increased energy expenditure. The compound is typically administered in oral form and has been studied for its pharmacokinetics, showing a relatively short half-life. Its mechanism of action involves the inhibition of the reuptake of key neurotransmitters, enhancing their availability in the synaptic cleft. Tesofensine has demonstrated efficacy in clinical trials, leading to significant weight loss in participants. However, like many pharmacological agents, it may be associated with side effects, including cardiovascular effects and potential impacts on mood. As research continues, the safety and long-term effects of Tesofensine are important considerations for its therapeutic use.

Formula: C₁₇H₂₃Cl₂NO

InChI: InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1

InChI key: InChIKey=VCVWXKKWDOJNIT-ZOMKSWQUSA-N

SMILES: C(OCC)[C@@H]1[C@H](C[C@]2(N(C)[C@@]1(CC2)[H])[H])C3=CC(Cl)=C(Cl)C=C3

Synonyms:

• NS 2330
• 8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, [1R-(2-endo,3-exo)]-
• 8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
• Tesofensine
• (1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane

Tesofensine

CAS: 195875-84-4

Formula: C₁₇H₂₃Cl₂NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 328.2766

Ref: IN-DA00ADN0

Tesofensine-13C-d3

CAS: 195875-84-4

Formula: C₁₆₁₃CH₂₀D₃Cl₂NO

Molecular weight: 332.29

Ref: 4Z-T-132002

Tesofensine-d5

CAS: 195875-84-4

Formula: C₁₇H₁₈D₅Cl₂NO

Molecular weight: 333.31

Ref: 4Z-T-132003

Tesofensine

CAS: 195875-84-4

Formula: C₁₇H₂₃Cl₂NO

Color and Shape: White To Off-White Solid

Molecular weight: 328.28

Ref: 4Z-T-132001

Tesofensine

Controlled Product

CAS: 195875-84-4

Applications Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
References Hansen, H., et al.: Pharmacology, Biochemistry and Behavior, 110, 265 (2013);

Formula: C₁₇H₂₃Cl₂NO

Color and Shape: Neat

Molecular weight: 328.28

Ref: TR-T136500

Tesofensine-d5

Controlled Product

CAS: 195875-84-4

Formula: C₁₇D₅H₁₈Cl₂NO

Color and Shape: Neat

Molecular weight: 333.307

Ref: TR-T136502

Tesofensine

CAS: 195875-84-4

Tesofensine, a serotonin–noradrenaline–dopamine reuptake inhibitor, is used potentially for the treatment of obesity.

Formula: C₁₇H₂₃Cl₂NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 328.28

Ref: TM-T28951