CAS 1961-77-9

chlormadinone

Description:

Chlormadinone is a synthetic progestin, primarily used in hormonal contraceptives and hormone replacement therapy. It is characterized by its chemical structure, which includes a steroid backbone with a chlorine atom and a ketone group, contributing to its biological activity. Chlormadinone exhibits anti-androgenic properties, making it effective in treating conditions like endometriosis and certain types of hormonal imbalances. The substance is typically administered orally and is known for its relatively long half-life, allowing for sustained therapeutic effects. Its mechanism of action involves binding to progesterone receptors, leading to alterations in the endometrial lining and inhibition of ovulation. Chlormadinone is generally well-tolerated, but like other hormonal agents, it may have side effects, including changes in menstrual patterns and potential cardiovascular risks. Due to its hormonal nature, it is contraindicated in certain populations, such as those with a history of thromboembolic disorders. Overall, chlormadinone is a valuable compound in reproductive health, with specific applications in contraception and hormone therapy.

Formula: C₂₁H₂₇ClO₃

InChI: InChI=1/C21H27ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,14-16,25H,4-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1

InChI key: InChIKey=VUHJZBBCZGVNDZ-TTYLFXKOSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C(Cl)=C3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]

Synonyms:

• (8Xi,10Xi,13Xi)-6-Chloro-17-Hydroxypregna-4,6-Diene-3,20-Dione
• 6-Chloro-17-Alpha-Hydroxypregna-4,6-Diene-3,20-Dione
• 6-Chloro-17-Hydroxypregna-4,6-Diene-3,20-Dione
• 6-Chloro-6-dehydro-17-hydroxyprogesterone
• 6-Chloro-6-dehydro-17α-hydroxyprogesterone
• Chlormadinon
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-
• Chlormadinone
• Chlormadinone Solution, 100ppm
• 20-dione,6-chloro-17-hydroxy-pregna-6-diene-3
• 6-Chloro-6-dehydro-17-
• Chlormadinone Acetate EP Imp J
• CHLORMADINON USP/EP/BP
• 6-Chloro-6-dehydro-17-α-hydroxyprogesterone
• hydroxyprogesterone

Chlormadinone (Chlormadinone Acetate EP Impurity J)

CAS: 1961-77-9

Formula: C₂₁H₂₇ClO₃

Color and Shape: Pale Yellow Solid

Molecular weight: 362.89

Ref: 4Z-C-652

Chlormadinone 100 µg/mL in Acetonitrile

CAS: 1961-77-9

Formula: C₂₁H₂₇ClO₃

Color and Shape: Single Solution

Molecular weight: 362.89

Ref: 04-A11327900AL-100

Chlormadinone

Controlled Product

CAS: 1961-77-9

Formula: C₂₁H₂₇ClO₃

Color and Shape: Neat

Molecular weight: 362.89

Ref: 04-C11327900

Chlormadinone

Controlled Product

CAS: 1961-77-9

Applications It has been used in combinations as an oral contraceptive.
References Brennan, D.M., et al.: Acta Endocrinol., 44, 367 (1963), Honma., s., et al.: Chem Pharm. Bull., 25 2019 (1977), Usui, T., et al.: Acta Urol. Jpn., 27, 327 (1981),

Formula: C₂₁H₂₇ClO₃

Color and Shape: Neat

Molecular weight: 362.89

Ref: TR-C343490

Chlormadinone

Controlled Product

CAS: 1961-77-9

Chlormadinone is a progestogen that is used as a contraceptive. It is an estrogen agonist and antagonist, which prevents the release of gonadotropins. Chlormadinone acetate is a synthetic steroid that has been shown to be effective in treating bacterial infections, including those caused by Neisseria gonorrhoeae and Chlamydia trachomatis. It also has synergistic effects with nomegestrol acetate, which may be due to its ability to inhibit the synthesis of prostaglandins.

Formula: C₂₁H₂₇ClO₃

Purity: Min. 95%

Molecular weight: 362.89 g/mol

Ref: 3D-BAA96177

Chlormadinone (free base)

CAS: 1961-77-9

Chlormadinone: synthetic hormone, treats BPH and PCOS, blocks androgen/estrogen, boosts bone cell growth.

Formula: C₂₁H₂₇ClO₃

Color and Shape: Solid

Molecular weight: 362.89

Ref: TM-T71904