CAS 196612-93-8

8-(3-Chloro-4-fluorophenylamino)-2-(1-methyl-4-piperidinylamino)pyrimido[5,4-d]pyrimidine

Description:

The chemical substance known as 8-(3-Chloro-4-fluorophenylamino)-2-(1-methyl-4-piperidinylamino)pyrimido[5,4-d]pyrimidine, with the CAS number 196612-93-8, is a synthetic compound that belongs to the class of pyrimidine derivatives. It is characterized by a complex molecular structure that includes multiple functional groups, such as amino and aromatic rings, which contribute to its biological activity. This compound is often studied for its potential pharmacological properties, particularly in the context of medicinal chemistry and drug development. Its unique arrangement of atoms allows for specific interactions with biological targets, making it a candidate for therapeutic applications. The presence of chlorine and fluorine substituents can influence its lipophilicity and metabolic stability, which are critical factors in drug design. Overall, this compound exemplifies the intricate relationship between molecular structure and biological function, highlighting the importance of chemical modifications in the development of effective pharmaceuticals.

Formula: C₁₈H₁₉ClFN₇

InChI: InChI=1/C18H19ClFN7/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24)

SMILES: CN1CCC(CC1)Nc1ncc2c(c(=Nc3ccc(c(c3)Cl)F)[nH]cn2)n1

Synonyms:

• Falnidamol
• Bibx-1382
• Bibx-1382Bs
• N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine
• N~8~-(3-chloro-4-fluorophenyl)-N~2~-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine

BIBX 1382 DIHYDROCHLORIDE

CAS: 196612-93-8

Formula: C₁₈H₁₉ClFN₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 387.8418

Ref: IN-DA00ABJ4

Falnidamol

CAS: 196612-93-8

Falnidamol

Purity: ≥95%

Molecular weight: 387.84g/mol

Ref: 54-BUP10091

Falnidamol

Controlled Product

CAS: 196612-93-8

Applications Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.
References Egeblad, M., et. al.: Biochem. Bioph. Res. Co., 281, 25 (2001)

Formula: C₁₈H₁₉ClFN₇

Color and Shape: Neat

Molecular weight: 387.84

Ref: TR-F101120

Falnidamol

CAS: 196612-93-8

Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.

Formula: C₁₈H₁₉ClFN₇

Purity: 98.816%

Color and Shape: Solid

Molecular weight: 387.84

Ref: TM-TQ0271