CAS 19685-09-7

Hydroxycamptothecin

Description:

Hydroxycamptothecin is a potent alkaloid derived from the plant Camptotheca acuminata, known for its anticancer properties. It belongs to the class of compounds called camptothecins, which are characterized by their ability to inhibit the enzyme topoisomerase I, leading to DNA damage and apoptosis in cancer cells. Hydroxycamptothecin exhibits a unique structure featuring a pentacyclic ring system, which is crucial for its biological activity. This compound is typically soluble in organic solvents and has limited solubility in water, which can pose challenges for formulation in pharmaceutical applications. Its therapeutic potential has been explored in various cancer types, including colorectal and ovarian cancers. However, its clinical use is often limited by issues such as toxicity and stability. Research continues to focus on improving its pharmacological profile and developing derivatives that enhance its efficacy and reduce side effects. Overall, Hydroxycamptothecin represents a significant compound in the field of cancer therapeutics, with ongoing studies aimed at optimizing its use in clinical settings.

Formula: C₂₀H₁₆N₂O₅

InChI: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

InChI key: InChIKey=HAWSQZCWOQZXHI-FQEVSTJZSA-N

SMILES: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O

Synonyms:

• (+/-)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
• (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 10-Hcpt
• 10-Hydroxy Camptothecin
• 10-Hydroxycamptothecin
• 10-Hydroxycamptothecine
• 10Hydroxy Camptothecin
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-
• 7-Ethy Hydroxycamptothecin
• Camptothecine, 10-hydroxy-
• ChEMBL 273862
• Hydroxy camptothecine
• Hydroxycamptothecin

10-Hydroxycamptothecin

CAS: 19685-09-7

Formula: C₂₀H₁₆N₂O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 364.36

Ref: 3B-H1463

Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 19685-09-7

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

Formula: C₂₀H₁₆N₂O₅

Color and Shape: Light Yellow Powder

Molecular weight: 364.10592

Ref: 45-1347610

(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CAS: 19685-09-7

Formula: C₂₀H₁₆N₂O₅

Purity: %

Color and Shape: Solid

Molecular weight: 364.3514

Ref: IN-DA0032GC

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin

Purity: 98%

Molecular weight: 364.35g/mol

Ref: 54-OR1008613

Irinotecan EP Impurity B (Irinotecan USP Related Compound A, 10-Hydroxy Camptothecin)

CAS: 19685-09-7

Formula: C₂₀H₁₆N₂O₅

Molecular weight: 364.36

Ref: 4Z-I-1838

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin

Purity: ≥98%

Molecular weight: 364.35g/mol

Ref: 54-BUP13827

(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ((S)-10-Hydroxycamptothecin)

CAS: 19685-09-7

Color and Shape: Neat

Ref: 86-MM1157.02

10-Hydroxycamptothecin

CAS: 19685-09-7

Formula: C₂₀H₁₆N₂O₅

Purity: 95%~99%

Molecular weight: 364.35

Ref: BP-BP0014

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.

Formula: C₂₀H₁₆N₂O₅

Purity: 99.09% - 99.81%

Color and Shape: Solid

Molecular weight: 364.35

Ref: TM-T2764

Irinotecan EP Impurity B

CAS: 19685-09-7

Formula: C₂₀H₁₆N₂O₅

Molecular weight: 364.36

Ref: ST-EA-CP-I9017

9-Hydroxycamptothecin

CAS: 19685-09-7

Formula: C₂₀H₁₆N₂O₅

Molecular weight: 364.36

Ref: ST-EA-CP-C88015

10-Hydroxy Camptothecin

Controlled Product

CAS: 19685-09-7

Impurity Irinotecan USP Related Compound A
Applications A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Irinotecan USP Related Compound A
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986), Miller, K.D., et al.: Invest. New Drugs, 22, 69 (2004), Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (2004), Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005),

Formula: C₂₀H₁₆N₂O₅

Color and Shape: Yellow

Molecular weight: 364.35

Ref: TR-H875000

10-Hydroxycamptothecin

CAS: 19685-09-7

10-Hydroxycamptothecin is an alkaloid, which is derived from the bark and stem of the Camptotheca acuminata tree, commonly known as the "Happy Tree." This compound is a potent topoisomerase I inhibitor. Its mode of action involves binding to the topoisomerase I-DNA complex, stabilizing it and thus preventing the re-ligation of DNA single-strand breaks. This interruption in the DNA replication process leads to DNA damage, ultimately triggering apoptosis in rapidly dividing cells.

Formula: C₂₀H₁₆N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 364.35 g/mol

Ref: 3D-FH16009

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

Purity: 98%

Molecular weight: 364.36

Ref: 10-F787618