CAS 19685-09-7: Hydroxycamptothecin

Description: Hydroxycamptothecin is a potent alkaloid derived from the plant Camptotheca acuminata, known for its anticancer properties. It belongs to the class of compounds called camptothecins, which are characterized by their ability to inhibit the enzyme topoisomerase I, leading to DNA damage and apoptosis in cancer cells. Hydroxycamptothecin exhibits a unique structure featuring a pentacyclic ring system, which is crucial for its biological activity. This compound is typically soluble in organic solvents and has limited solubility in water, which can pose challenges for formulation in pharmaceutical applications. Its therapeutic potential has been explored in various cancer types, including colorectal and ovarian cancers. However, its clinical use is often limited by issues such as toxicity and stability. Research continues to focus on improving its pharmacological profile and developing derivatives that enhance its efficacy and reduce side effects. Overall, Hydroxycamptothecin represents a significant compound in the field of cancer therapeutics, with ongoing studies aimed at optimizing its use in clinical settings.

Formula: C₂₀H₁₆N₂O₅

InChI: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

InChI key: InChIKey=HAWSQZCWOQZXHI-FQEVSTJZSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC(O)=CC5=CC4C3

Synonyms:

• (+/-)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
• (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 10-Hcpt
• 10-Hydroxy Camptothecin
• 10-Hydroxycamptothecin
• 10-Hydroxycamptothecine
• 10Hydroxy Camptothecin
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-
• 7-Ethy Hydroxycamptothecin
• Camptothecine, 10-hydroxy-
• ChEMBL 273862
• Hydroxy camptothecine
• Hydroxycamptothecin
• NSC 107124

10-Hydroxycamptothecin

CAS: 19685-09-7

• Formula: C₂₀H₁₆N₂O₅
• Purity: >98.0%(HPLC)
• Color and Shape: White to Yellow to Orange powder to crystal
• Molecular weight: 364.36

Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 19685-09-7

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

• Formula: C₂₀H₁₆N₂O₅
• Color and Shape: Light Yellow Powder
• Molecular weight: 364.10592

(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CAS: 19685-09-7

• Formula: C₂₀H₁₆N₂O₅
• Purity: %
• Color and Shape: Solid
• Molecular weight: 364.3514

Irinotecan EP Impurity B (Irinotecan USP Related Compound A, 10-Hydroxy Camptothecin)

CAS: 19685-09-7

• Formula: C₂₀H₁₆N₂O₅
• Molecular weight: 364.36

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

• Purity: 98%+
• Molecular weight: 364.35g/mol

10-Hydroxycamptothecin

CAS: 19685-09-7

• Formula: C₂₀H₁₆N₂O₅
• Purity: 95%~99%
• Molecular weight: 364.35

(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ((S)-10-Hydroxycamptothecin)

CAS: 19685-09-7

• Formula: C₂₀H₁₆N₂O₅
• Color and Shape: Neat
• Molecular weight: 364.35

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against …

• Formula: C₂₀H₁₆N₂O₅
• Purity: 99.09% - 99.81%
• Color and Shape: Solid
• Molecular weight: 364.35

10-Hydroxy Camptothecin

CAS: 19685-09-7

Impurity Irinotecan USP Related Compound A Applications A Camptothecin derivative; a topoisomerase inhibitor for cancer …

• Formula: C₂₀H₁₆N₂O₅
• Color and Shape: Yellow
• Molecular weight: 364.35

10-Hydroxycamptothecin

CAS: 19685-09-7

Please enquire for more information about 10-Hydroxycamptothecin including the price, delivery time and more detailed …

• Formula: C₂₀H₁₆N₂O₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 364.35 g/mol