CAS 19685-10-0: 9-Methoxycamptothecin

Description:9-Methoxycamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This substance is characterized by its unique structure, which includes a lactone ring that is crucial for its biological activity. It exhibits potent antitumor properties, primarily through its mechanism of action as a topoisomerase I inhibitor, disrupting DNA replication and transcription in cancer cells. The methoxy group at the 9-position enhances its solubility and bioavailability compared to its parent compound. 9-Methoxycamptothecin has been studied for its efficacy against various cancer types, including colorectal and lung cancers. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile. Additionally, ongoing research aims to optimize its formulation and delivery methods to improve its clinical application while minimizing side effects. Overall, 9-Methoxycamptothecin represents a significant focus in cancer chemotherapy research due to its promising antitumor activity.

Formula:C₂₁H₁₈N₂O₅

InChI:InChI=1/C21H18N2O5/c1-3-21(26)15-8-17-18-12(6-11-7-13(27-2)4-5-16(11)22-18)9-23(17)19(24)14(15)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3

Synonyms:
Methoxycamptothecin, 9-
10-Methoxycamptothecin
Camptothecin, methoxy-
Methoxycamptothecin
Nsc 111533
Camptothecine, 10-methoxy-
4-ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Found 4 products.

Product data	Purity	Price range	Estimated delivery
10-Methoxycamptothecin REF: 54-BUP01387CAS: 19685-10-0	98.8%	379.00 €~885.00 €	Tue 15 Apr 25
10-Methoxycamptothecin REF: 7W-GY9328CAS: 19685-10-0	- - -	To inquire	Tue 15 Apr 25
10-Methoxycamptothecin REF: BP-BP0016CAS: 19685-10-0	95%~99%	365.00 €	Tue 15 Apr 25
10-Methoxycamptothecin REF: TM-T4S1951CAS: 19685-10-0	98.81%	48.00 €~413.00 €	Mon 28 Jul 25