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CAS 19685-10-0

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9-Methoxycamptothecin

Description:
9-Methoxycamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This substance is characterized by its unique structure, which includes a lactone ring that is crucial for its biological activity. It exhibits potent antitumor properties, primarily through its mechanism of action as a topoisomerase I inhibitor, disrupting DNA replication and transcription in cancer cells. The methoxy group at the 9-position enhances its solubility and bioavailability compared to its parent compound. 9-Methoxycamptothecin has been studied for its efficacy against various cancer types, including colorectal and lung cancers. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile. Additionally, ongoing research aims to optimize its formulation and delivery methods to improve its clinical application while minimizing side effects. Overall, 9-Methoxycamptothecin represents a significant focus in cancer chemotherapy research due to its promising antitumor activity.
Formula:C21H18N2O5
InChI:InChI=1/C21H18N2O5/c1-3-21(26)15-8-17-18-12(6-11-7-13(27-2)4-5-16(11)22-18)9-23(17)19(24)14(15)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3
SMILES:CCC1(c2cc3c4c(cc5cc(ccc5n4)OC)Cn3c(=O)c2COC1=O)O
Synonyms:
  • Methoxycamptothecin, 9-
  • 10-Methoxycamptothecin
  • Camptothecin, methoxy-
  • Methoxycamptothecin
  • Nsc 111533
  • Camptothecine, 10-methoxy-
  • 4-ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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