CAS 196868-63-0

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

Description:

IGF-1R Inhibitor II, with the chemical name N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea and CAS number 196868-63-0, is a small molecule inhibitor specifically targeting the insulin-like growth factor 1 receptor (IGF-1R). This compound is characterized by its unique structural features, including a chloro-substituted methoxyphenyl group and a methylquinoline moiety, which contribute to its biological activity. IGF-1R plays a crucial role in cell growth, proliferation, and survival, making this inhibitor of interest in cancer research and therapeutic development. The compound is typically studied for its potential to impede tumor growth by disrupting IGF signaling pathways. In terms of solubility and stability, it is essential to consider the specific conditions under which the compound is handled, as these factors can influence its efficacy and application in biological systems. Overall, IGF-1R Inhibitor II represents a valuable tool in the exploration of targeted cancer therapies.

Formula: C₁₈H₁₆ClN₃O₂

Synonyms:

• Pq401
• Pq-401
• N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
• N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
• Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-
• 1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea
• IGF-1R Inhibitor II

PQ401

CAS: 196868-63-0

PQ401

Purity: ≥98%

Molecular weight: 341.79g/mol

Ref: 54-BUP10782

1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-Yl)Urea

CAS: 196868-63-0

1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-Yl)Urea

Purity: 98%

Molecular weight: 341.79g/mol

Ref: 54-OR1026348

PQ401

CAS: 196868-63-0

PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).

Formula: C₁₈H₁₆ClN₃O₂

Purity: 99.77%

Color and Shape: Solid

Molecular weight: 341.79

Ref: TM-T2085

PQ401

CAS: 196868-63-0

Formula: C₁₈H₁₆ClN₃O₂

Molecular weight: 341.79

Ref: 7W-GK0750

PQ401

CAS: 196868-63-0

Formula: C₁₈H₁₆ClN₃O₂

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 341.80

Ref: 3B-P2479

1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea

CAS: 196868-63-0

Formula: C₁₈H₁₆ClN₃O₂

Purity: 99%

Molecular weight: 341.8

Ref: 10-F320489

PQ401

CAS: 196868-63-0

PQ401 is a collagen gel that has been shown to improve the metabolic rate of cancer cells. PQ401 is a synthetic peptide with anti-cancer properties that inhibits the production of fatty acids and IGF-I, which are required for cell proliferation. PQ401 has been shown to inhibit the growth of squamous carcinoma and carcinoma cell lines in vitro. This drug also inhibits the growth of galleria mellonella larvae, an insect model system for skin cancer. PQ401 has also been shown to inhibit tyrosine kinase domain proteins in adrenocortical carcinoma cells.

Formula: C₁₈H₁₆ClN₃O₂

Purity: Min. 95%

Molecular weight: 341.79 g/mol

Ref: 3D-WHA86863