CAS 197502-82-2: Parecoxib sodium

Description:Parecoxib sodium is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used for the management of pain and inflammation, particularly in postoperative settings. Parecoxib is a prodrug, which means it is converted into its active form, valdecoxib, in the body. The substance is characterized by its sodium salt form, which enhances its solubility in water, facilitating intravenous administration. Parecoxib sodium exhibits analgesic and anti-inflammatory properties by selectively inhibiting the COX-2 enzyme, thereby reducing the production of prostaglandins involved in pain and inflammation. It is generally well-tolerated, but like other NSAIDs, it may have side effects, including gastrointestinal issues and cardiovascular risks. The drug is typically administered in a clinical setting, and its use is subject to regulatory guidelines to ensure safety and efficacy. As with any medication, it is important to consider individual patient factors and potential drug interactions when prescribing parecoxib sodium.

Formula:C₁₉H₁₈N₂O₄S·Na

InChI:InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);

InChI key:InChIKey=IMBMHWVEMVJSIQ-UHFFFAOYSA-N

SMILES:[Na].O=C(NS(=O)(=O)C1=CC=C(C=C1)C=2C(=NOC2C)C=3C=CC=CC3)CC

Synonyms:
N-[[p-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propionamide Sodium Salt
Parecoxib sodium
[[4-(5-methyl-3-phenyl-isoxazol-4-yl)phenyl]sulfonyl-propanoyl-amino]sodium
Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt
sodium (1Z)-N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanimidate
SC 69124A
Dynastat
Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (1:1)
N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt