CAS 19767-45-4

Mesna

Description:

Mesna, or 2-mercaptoethanesulfonate, is a synthetic thiol compound primarily used as a chemoprotective agent in oncology. It is characterized by its ability to detoxify harmful metabolites of certain chemotherapeutic agents, particularly ifosfamide and cyclophosphamide, thereby reducing the risk of hemorrhagic cystitis. Mesna is a water-soluble compound, which allows for easy administration via intravenous or oral routes. Its mechanism of action involves the conjugation of its thiol group with toxic metabolites, facilitating their excretion through the urine. Mesna is generally well-tolerated, with a low incidence of side effects, although some patients may experience mild gastrointestinal disturbances. The compound is often administered alongside chemotherapy regimens to enhance patient safety and treatment efficacy. Its chemical structure includes a sulfonate group, which contributes to its solubility and reactivity. Overall, Mesna plays a crucial role in supportive cancer care, helping to mitigate the adverse effects of certain chemotherapeutic agents.

Formula: C₂H₆O₃S₂·Na

InChI: InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);

InChI key: InChIKey=PYTISYCTLQTCTM-UHFFFAOYSA-N

SMILES: C(S(=O)(=O)O)CS.[Na]

Synonyms:

• 2-Mercapto-1-ethanesulfonic acid monosodium salt
• 2-Mercaptoethanesulfonic acid monosodium salt
• 2-Mercaptoethanesulfonic acid sodium salt
• 2-Mercaptoethanesulphonicacid,sodiumsalt
• D 7093
• Ethanesulfonic Acid, 2-Mercapto-, Sodium Salt (1:1)
• Ethanesulfonic acid, 2-mercapto-, monosodium salt
• Mesna
• Mesnex
• Mesnum
• Mistabron
• Mistabronco
• Mitexan
• Mucofluid
• Prehepon
• Sodium 2-Sulfanylethanesulfonate
• Ucb 3983
• Uromitexan

Sodium 2-Mercaptoethanesulfonate

CAS: 19767-45-4

Formula: C₂H₅NaO₃S₂

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 164.17

Ref: 3B-M0913

2-Mercaptoethane sulfonic acid sodium salt, 96%

CAS: 19767-45-4

2-Mercaptoethane sulfonic acid sodium salt is used as an adjuvant in cancer chemotherapy involving cyclophosphamide and ifosfamide. It is used as an antioxidant and cytoprotective agent in a wide variety of applications from protection from toxicity of therapeutic agents, such as cyclophosphamide to

Formula: C₂H₆NaO₃S₂

Purity: 96%

Molecular weight: 164.18

Ref: 02-J63989

Mesna

CAS: 19767-45-4

Organo-sulfur compounds, nesoi

Formula: C₂H₅NaO₃S₂

Color and Shape: White Yellow Powder

Molecular weight: 163.95778

Ref: 45-1392807

Sodium 2-mercaptoethanesulfonate

CAS: 19767-45-4

Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic.

Formula: C₂H₅NaO₃S₂

Purity: 99.88% - 99.89%

Color and Shape: Solid

Molecular weight: 164.18

Ref: TM-T1414

Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1)

CAS: 19767-45-4

Formula: C₂H₅NaO₃S₂

Purity: 90%

Color and Shape: Solid

Molecular weight: 164.1791

Ref: IN-DA002AYN

Mesna

CAS: 19767-45-4

Formula: C₂H₅NaO₃S₂

Purity: 96.0 - 102.0 % (anhydrous basis)

Color and Shape: White to pale yellow crystalline powder or crystals

Molecular weight: 164.18

Ref: 7W-GP4428

Sodium 2-mercaptoethanesulfonate

CAS: 19767-45-4

Sodium 2-mercaptoethanesulfonate

Purity: 95%

Molecular weight: 164.18g/mol

Ref: 54-OR1014967

Mesna

CAS: 19767-45-4

Formula: C₂H₅O₃S₂·Na

Molecular weight: 141.18 22.99

Ref: 4Z-M-095011

Sodium 2-mercaptoethanesulfonate

CAS: 19767-45-4

Sodium 2-mercaptoethanesulfonate

Purity: ≥98%

Molecular weight: 164.18g/mol

Ref: 54-BUP19581

Mesna

Controlled Product

CAS: 19767-45-4

Formula: C₂H₅O₃S₂·Na

Color and Shape: White Solid

Molecular weight: 164.18

Ref: 86-MM0345.00

Sodium 2-mercaptoethanesulfonate

CAS: 19767-45-4

Formula: C₂H₅NaO₃S₂

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 164.17

Ref: 10-F036581

Mesna

CAS: 19767-45-4

Applications Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.
References Tekeres, M., et al.: Clin. Ther., 4, 56 (1981), Brock, N., et al.: Eur. J. Cancer Clin Oncol., 18, 1377 (1982), James, C.A., et al.: Br. J. Clin. Pharmacol., 23, 561 (1987), Schoenike, S.E., et al.: Clin. Pharm., 9, 179 (1990),

Formula: C₂H₅O₃S₂·Na

Color and Shape: Neat

Molecular weight: 164.18

Ref: TR-M225750

Mesna

CAS: 19767-45-4

Reduces toxic effects of chemotherapeutic agents on urinary tract

Formula: C₂H₅NaO₃S₂

Purity: Min. 90%

Color and Shape: Powder

Molecular weight: 164.18 g/mol

Ref: 3D-FM25114