CAS 1977-15-7

2-Hydroxydesipramine

Description:

2-Hydroxydesipramine is a chemical compound that belongs to the class of tricyclic antidepressants. It is a derivative of desipramine, which is itself a metabolite of the antidepressant imipramine. The compound is characterized by the presence of a hydroxyl group (-OH) at the second position of the phenyl ring, which influences its pharmacological properties. 2-Hydroxydesipramine exhibits a mechanism of action primarily through the inhibition of the reuptake of norepinephrine and serotonin, contributing to its antidepressant effects. It is known to have a relatively high affinity for norepinephrine transporters compared to serotonin transporters. The compound's pharmacokinetics, including absorption, distribution, metabolism, and excretion, can vary based on individual factors and the presence of other medications. Additionally, like other tricyclic antidepressants, it may have side effects such as sedation, dry mouth, and potential cardiovascular effects. Due to its specific chemical structure and properties, 2-Hydroxydesipramine is of interest in both clinical and research settings, particularly in the study of mood disorders.

Formula: C₁₈H₂₂N₂O

InChI: InChI=1S/C18H22N2O/c1-19-11-4-12-20-17-6-3-2-5-14(17)7-8-15-13-16(21)9-10-18(15)20/h2-3,5-6,9-10,13,19,21H,4,7-8,11-12H2,1H3

InChI key: InChIKey=NVJBOLMRGMDGLD-UHFFFAOYSA-N

SMILES: C(CCNC)N1C=2C(CCC=3C1=CC=CC3)=CC(O)=CC2

Synonyms:

• 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol
• 2-Hydroxydemethylimipramine
• 2-Hydroxydesipramine
• 2-Hydroxydesmethylimipramine
• 5-[3-(methylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepin-2-ol
• 5H-Dibenz[b,f]azepin-2-ol, 10,11-dihydro-5-[3-(methylamino)propyl]-
• Gp 36329

2-Hydroxy Desipramine

CAS: 1977-15-7

Formula: C₁₈H₂₂N₂O

Color and Shape: Off-White Solid

Molecular weight: 282.39

Ref: 4Z-D-021

2-Hydroxy Desipramine-d6

CAS: 1977-15-7

Formula: C₁₈H₁₆D₆N₂O

Color and Shape: Off-White Solid

Molecular weight: 288.42

Ref: 4Z-D-022

2-Hydroxy Desipramine

Controlled Product

CAS: 1977-15-7

Applications A metabolite of Desipramine.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),

Formula: C₁₈H₂₂N₂O

Color and Shape: Light Brown To Beige

Molecular weight: 282.38

Ref: TR-H936500

2-Hydroxy Desipramine

CAS: 1977-15-7

Formula: C₁₈H₂₂N₂O

Molecular weight: 282.4

Ref: ST-EA-CP-D34002