CAS 197904-84-0

Apricoxib

Description:

Apricoxib is a chemical compound classified as a selective COX-2 inhibitor, primarily developed for its anti-inflammatory and analgesic properties. It is part of the nonsteroidal anti-inflammatory drug (NSAID) class, which targets the cyclooxygenase enzymes involved in the inflammatory process. Apricoxib exhibits a high affinity for the COX-2 enzyme while sparing COX-1, which is responsible for maintaining gastric mucosa and platelet function, thus potentially reducing gastrointestinal side effects commonly associated with traditional NSAIDs. The compound is characterized by its specific molecular structure, which contributes to its pharmacological activity. Apricoxib has been investigated for its efficacy in treating conditions such as arthritis and other inflammatory disorders. However, as with any medication, it is essential to consider its safety profile, potential side effects, and contraindications. Research and clinical trials are crucial for understanding its therapeutic potential and optimizing its use in clinical settings.

Formula: C₁₉H₂₀N₂O₃S

InChI: InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)

InChI key: InChIKey=JTMITOKKUMVWRT-UHFFFAOYSA-N

SMILES: CC=1C=C(N(C1)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC=C(OCC)C=C3

Synonyms:

• 4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide
• Apricoxib
• 4-Methyl-2-(4-ethoxyphenyl)-1-(4-sulfamoylphenyl)pyrrole
• Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-
• CS 706

Apricoxib

Controlled Product

CAS: 197904-84-0

Applications Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.
References Kirane, A, et al.: Clinical Cancer Res., 18, 5031 (2012); Rohatagi, Sh., et al.: British J. Clin. Pharmaco., 66, 60 (2008);

Formula: C₁₉H₂₀N₂O₃S

Color and Shape: Neat

Molecular weight: 356.44

Ref: TR-A729850

Apricoxib-d4

Controlled Product

CAS: 197904-84-0

Formula: C₁₉D₄H₁₆N₂O₃S

Color and Shape: Neat

Molecular weight: 360.463

Ref: TR-A729852

Apricoxib

CAS: 197904-84-0

Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.

Formula: C₁₉H₂₀N₂O₃S

Color and Shape: Solid

Molecular weight: 356.44

Ref: TM-T70018