CAS 198062-54-3

(3s,3as,6ar)-3-isopropyl-1-(methanesulfonyl)-4-[4-(1-piperidinyl)-2(e)-butenoyl]perhydropyrrolo[3,2b]pyrrol-2(1h)-one hydrochloride

Description:

The chemical substance known as (3s,3as,6ar)-3-isopropyl-1-(methanesulfonyl)-4-[4-(1-piperidinyl)-2(e)-butenoyl]perhydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride, with the CAS number 198062-54-3, is a complex organic compound characterized by its multi-cyclic structure and various functional groups. It features a perhydropyrrolo framework, which contributes to its potential biological activity. The presence of an isopropyl group and a methanesulfonyl moiety suggests that it may exhibit specific interactions with biological targets, possibly influencing its pharmacological properties. The inclusion of a piperidinyl group indicates potential for central nervous system activity, as piperidine derivatives are often associated with neuroactive compounds. Additionally, the hydrochloride salt form enhances its solubility in aqueous environments, which is beneficial for drug formulation and delivery. Overall, this compound's structural complexity and functional diversity suggest it may have significant implications in medicinal chemistry, particularly in the development of therapeutics targeting various biological pathways.

Formula: C₁₉H₃₂ClN₃O₄S

InChI: InChI=1/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17?,18-;/m1./s1

Synonyms:

• (3S,3As,6Ar)-Hexahydro-3-(1-Methylethyl)-1-(Methylsulfonyl)-4-[(2E)-1-Oxo-4-(1-Piperidinyl)-2-Butenyl]Pyrrolo[3,2-B]Pyrrol-2(1H)-One Hydrochloride
• Gw311616A
• Gw 311616 Hydrochloride
• (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-((2E)-1-oxo-4-(1-piperidinyl)-2-butenyl)pyrrolo[3.2-b]pyrr
• GW311616HCl
• (3aR,6aS)-6-isopropyl-4-methylsulfonyl-1-[(E)-4-(1-piperidyl)but-2-enoyl]-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one hydrochloride

GW 311616

CAS: 198062-54-3

GW 311616 is a natural compound that has been shown to have therapeutic benefits in animal models of bowel disease. It has been demonstrated to be efficacious in vivo, and it was found to be an ATP-binding cassette transporter inhibitor. GW 311616 also inhibits the inflammatory response by inhibiting the production of pro-inflammatory cytokines and chemokines. Clinical trials are currently underway for GW 311616 as a potential treatment for autoimmune diseases, including inflammatory bowel disease. This drug is not yet approved for human use.

Formula: C₁₉H₃₁N₃O₄S

Purity: Min. 95%

Molecular weight: 397.53 g/mol

Ref: 3D-BG168512

GW311616

CAS: 198062-54-3

GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

Formula: C₁₉H₃₁N₃O₄S

Color and Shape: Solid

Molecular weight: 397.53

Ref: TM-T11525