5-(E-2-Carbomethoxyvinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite, with CAS number 198080-38-5, is a specialized nucleoside phosphoramidite used primarily in the synthesis of oligonucleotides. This compound features a deoxyuridine base, which is a nucleoside component of DNA, modified with a carbomethoxyvinyl group that enhances its reactivity in coupling reactions. The presence of the 4,4'-dimethoxytrityl protecting group allows for selective protection of the 5' hydroxyl group, facilitating the stepwise assembly of oligonucleotides. The 3'-phosphoramidite moiety, which includes a cyanoethyl group and diisopropylamine, is crucial for the activation and coupling of the nucleoside during oligonucleotide synthesis. This compound is typically utilized in automated synthesizers and is valued for its stability and efficiency in forming phosphodiester bonds. Its unique structural features contribute to the development of custom DNA sequences for research, therapeutic applications, and diagnostics in molecular biology.

5-(E-2-CARBOMETHOXYVINYL)-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYURIDINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE

198080-38-5: 5-(E-2-Carbomethoxyvinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite, with CAS number 198080-38-5, is a specialized nucleoside phosphoramidite used primarily in the synthesis of oligonucleotides. This compound features a deoxyuridine base, which is a nucleoside component of DNA, modified with a carbomethoxyvinyl group that enhances its reactivity in coupling reactions. The presence of the 4,4'-dimethoxytrityl protecting group allows for selective protection of the 5' hydroxyl group, facilitating the stepwise assembly of oligonucleotides. The 3'-phosphoramidite moiety, which includes a cyanoethyl group and diisopropylamine, is crucial for the activation and coupling of the nucleoside during oligonucleotide synthesis. This compound is typically utilized in automated synthesizers and is valued for its stability and efficiency in forming phosphodiester bonds. Its unique structural features contribute to the development of custom DNA sequences for research, therapeutic applications, and diagnostics in molecular biology.

<p>2'-Deoxy-5'-O-DMT-5-(3-methacryloyl)uridine 3'-CE phosphoramidite is a synthetic nucleoside analogue. It is an antiviral and anticancer agent that inhibits viral DNA synthesis by inhibiting the enzyme DNA polymerase. The compound also induces apoptosis in cancer cells by inhibiting RNA synthesis. 2'-Deoxy-5'-O-DMT-5-(3-methacryloyl)uridine 3'-CE phosphoramidite has been shown to be cytotoxic to human breast cancer cells, and is currently being studied as a potential treatment for prostate cancer.</p>

CAS 198080-38-5

5-(E-2-CARBOMETHOXYVINYL)-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYURIDINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE

2'-Deoxy-5'-O-DMT-5-(3-methacryloyl)uridine 3'-CE phosphoramidite

Ref: 3D-PD09142