CAS 19815-18-0
:4-Chloro-8-nitroquinazoline
Description:
4-Chloro-8-nitroquinazoline is a heterocyclic organic compound characterized by its quinazoline structure, which consists of a fused benzene and pyrimidine ring. The presence of a chlorine atom at the 4-position and a nitro group at the 8-position contributes to its unique chemical properties. This compound is typically a yellow to orange crystalline solid and is sparingly soluble in water but more soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). It exhibits notable biological activity, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting various diseases. The nitro group can participate in reduction reactions, potentially leading to different derivatives, while the chloro substituent can serve as a site for further chemical modifications. As with many nitro compounds, it may pose certain safety concerns, including toxicity and environmental impact, necessitating careful handling and disposal. Overall, 4-Chloro-8-nitroquinazoline is a compound of significant interest in both research and application contexts.
Formula:C8H4ClN3O2
InChI:InChI=1S/C8H4ClN3O2/c9-8-5-2-1-3-6(12(13)14)7(5)10-4-11-8/h1-4H
InChI key:InChIKey=YNIKQCKETYIRTH-UHFFFAOYSA-N
SMILES:N(=O)(=O)C=1C2=C(C(Cl)=NC=N2)C=CC1
Synonyms:- 4-Chloro-8-nitroquinazoline
- Quinazoline, 4-chloro-8-nitro-
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Found 2 products.
4-Chloro-8-nitroquinazoline
CAS:4-Chloro-8-nitroquinazoline is a potent antiproliferative agent that binds to the FGFR3 receptor and inhibits the proliferation of bladder cancer cells. It also has potent activity against bladder cancer cells in culture and inhibits cell growth by binding to submicromolar concentrations of this protein. 4-Chloro-8-nitroquinazoline may be useful for the treatment of bladder cancer, which is a disease characterized by uncontrolled cell division. This drug can inhibit proliferation of bladder cancer cells by interfering with their ability to signal through FGFR3 receptors, thereby inhibiting the activation of downstream signaling pathways that regulate cell cycle progression.
Formula:C8H4ClN3O2Purity:Min. 95%Molecular weight:209.59 g/mol
