CAS 19847-10-0

2-Pyrazinecarbonyl chloride

Description:

2-Pyrazinecarbonyl chloride, with the CAS number 19847-10-0, is an organic compound characterized by the presence of a pyrazine ring and a carbonyl chloride functional group. It is a colorless to pale yellow liquid that is typically used as an acylating agent in organic synthesis. The compound is known for its reactivity, particularly due to the electrophilic nature of the carbonyl carbon, which makes it suitable for reactions with nucleophiles. It is soluble in organic solvents such as dichloromethane and ether but is generally not soluble in water. 2-Pyrazinecarbonyl chloride is sensitive to moisture and can hydrolyze to form 2-pyrazinecarboxylic acid and hydrochloric acid upon exposure to water. Safety precautions are essential when handling this compound, as it can be corrosive and irritating to the skin, eyes, and respiratory system. Proper storage in a cool, dry place, away from moisture and incompatible substances, is recommended to maintain its stability and reactivity.

Formula: C₅H₃ClN₂O

InChI: InChI=1/C5H3ClN2O/c6-5(9)4-3-7-1-2-8-4/h1-3H

InChI key: InChIKey=TXJKATOSKLUITR-UHFFFAOYSA-N

SMILES: C(Cl)(=O)C=1C=NC=CN1

Synonyms:

• Pyrazine-2-carbonyl chloride
• Pyrazine-2-carboxylic acid chloride
• Pyrazinecarbonyl chloride
• Pyrazinoic acid chloride
• Pyrazinoyl chloride
• 2-Pyrazinecarbonyl chloride
• 2-PYRAZINECARBONYL CHLORIDE: TECH.
• ASINEX-REAG BAS 07703829
• TIMTEC-BB SBB010290

Pyrazine-2-carbonyl chloride, 90+%

CAS: 19847-10-0

Pyrazine-2-carbonyl chloride is used as pharmaceutical intermediates. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU ref

Formula: C₅H₃ClN₂O

Purity: 90+%

Color and Shape: Powder and/or lumpy powder, Purple to dark purple

Molecular weight: 142.54

Ref: 02-H50418

Pyrazine-2-carbonyl chloride

CAS: 19847-10-0

Formula: C₅H₃ClN₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 142.5431

Ref: IN-DA002BJC

2-Pyrazinecarbonyl chloride

CAS: 19847-10-0

2-Pyrazinecarbonyl chloride

Purity: 95%

Molecular weight: 142.54g/mol

Ref: 54-OR912568

2-Pyrazinecarbonyl Chloride

Controlled Product

CAS: 19847-10-0

Applications 2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

Formula: C₅H₃ClN₂O

Color and Shape: Neat

Molecular weight: 142.543

Ref: TR-P840805

Pyrazine-2-carbonyl Chloride

CAS: 19847-10-0

Formula: C₅H₃ClN₂O

Molecular weight: 142.54

Ref: ST-EA-CP-B34103