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CAS 198470-84-7

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Parecoxib

Description:
Parecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily used as a nonsteroidal anti-inflammatory drug (NSAID) for the management of pain and inflammation. It is characterized by its ability to reduce pain without significantly affecting the gastrointestinal tract, a common side effect associated with non-selective NSAIDs. Parecoxib is typically administered in its prodrug form, which is converted to its active metabolite, valdecoxib, in the body. The substance is soluble in organic solvents and has a relatively low solubility in water, which influences its formulation and delivery methods. Parecoxib is often used in postoperative pain management and has been studied for its efficacy in various pain conditions. However, its use has been associated with cardiovascular risks, similar to other COX-2 inhibitors, leading to careful consideration in clinical settings. As with any medication, monitoring for side effects and contraindications is essential during its use.
Formula:C19H18N2O4S
InChI:InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)
InChI key:InChIKey=TZRHLKRLEZJVIJ-UHFFFAOYSA-N
SMILES:CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3
Synonyms:
  • Dynastat
  • N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide
  • N-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide
  • N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide
  • Parecoxib [USAN:INN:BAN]
  • Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-
  • Sc 69124
  • Unii-9Tuw81Y3Ce
  • Valus-P
  • See more synonyms
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Found 12 products.