CAS 198470-84-7: Parecoxib

Description: Parecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily used as a nonsteroidal anti-inflammatory drug (NSAID) for the management of pain and inflammation. It is characterized by its ability to reduce pain without significantly affecting the gastrointestinal tract, a common side effect associated with non-selective NSAIDs. Parecoxib is typically administered in its prodrug form, which is converted to its active metabolite, valdecoxib, in the body. The substance is soluble in organic solvents and has a relatively low solubility in water, which influences its formulation and delivery methods. Parecoxib is often used in postoperative pain management and has been studied for its efficacy in various pain conditions. However, its use has been associated with cardiovascular risks, similar to other COX-2 inhibitors, leading to careful consideration in clinical settings. As with any medication, monitoring for side effects and contraindications is essential during its use.

Formula: C₁₉H₁₈N₂O₄S

InChI: InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)

InChI key: InChIKey=TZRHLKRLEZJVIJ-UHFFFAOYSA-N

SMILES: O=C(NS(=O)(=O)C1=CC=C(C=C1)C=2C(=NOC2C)C=3C=CC=CC3)CC

Synonyms:

• Dynastat
• N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide
• N-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide
• N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide
• N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide
• Parecoxib [USAN:INN:BAN]
• Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-
• Sc 69124
• Unii-9Tuw81Y3Ce
• Valus-P
• Vorth-P
• Xapit
• Parecoxib

Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-

CAS: 198470-84-7

• Formula: C₁₉H₁₈N₂O₄S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 370.4222

Valdecoxib Impurity 38

CAS: 198470-84-7

• Formula: C₁₉H₁₈N₂O₄S
• Color and Shape: White To Off-White Solid
• Molecular weight: 370.43

Parecoxib

CAS: 198470-84-7

• Formula: C₁₉H₁₈N₂O₄S
• Color and Shape: Neat
• Molecular weight: 370.42

Parecoxib

CAS: 198470-84-7

• Formula: C₁₉H₁₈N₂O₄S
• Purity: >97.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 370.42

Parecoxib

CAS: 198470-84-7

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

• Formula: C₁₉H₁₈N₂O₄S
• Purity: 99.78% - 99.90%
• Color and Shape: Solid
• Molecular weight: 370.42

Parecoxib

CAS: 198470-84-7

N-((4-(5-Methyl-3-phenyl-2,3-dihydrooxazol-4-yl)phenyl)sulfonyl)propionamide

CAS: 198470-84-7

• Purity: 95.0%
• Molecular weight: 372.44000244140625

Parecoxib

CAS: 198470-84-7

Applications Parecoxib is used in the combination with Telmisartan for the treatment of endometriosis. Parecoxib …

• Formula: C₁₉H₁₈N₂O₄S
• Color and Shape: Neat
• Molecular weight: 370.42

N-[4-(5-Methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide

CAS: 198470-84-7

N-[4-(5-Methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide (NSO) is a drug with both antibiotic and anti-inflammatory properties. It is a potent …

• Formula: C₁₉H₁₈N₂O₄S
• Purity: Min. 95%
• Molecular weight: 370.42 g/mol