CAS 198480-55-6

2-(4-Hydroxyphenyl)-3-methyl-1-[4-[2-(1-piperidinyl)ethoxy]benzyl]-1H-indol-5-ol

Description:

2-(4-Hydroxyphenyl)-3-methyl-1-[4-[2-(1-piperidinyl)ethoxy]benzyl]-1H-indol-5-ol, with the CAS number 198480-55-6, is a synthetic organic compound characterized by its complex molecular structure, which includes an indole core, hydroxyl groups, and a piperidine moiety. This compound exhibits properties typical of indole derivatives, such as potential biological activity, including interactions with various receptors or enzymes. The presence of the hydroxyl group suggests it may engage in hydrogen bonding, enhancing its solubility in polar solvents. The piperidine ring contributes to its pharmacological profile, potentially influencing its binding affinity and selectivity for biological targets. Additionally, the ethoxy and benzyl substituents may enhance lipophilicity, affecting its distribution in biological systems. Overall, this compound's unique structure may render it of interest in medicinal chemistry, particularly in the development of therapeutic agents. However, specific biological activities and applications would require further investigation through experimental studies.

Formula: C₂₉H₃₂N₂O₃

InChI: InChI=1/C29H32N2O3/c1-21-27-19-25(33)11-14-28(27)31(29(21)23-7-9-24(32)10-8-23)20-22-5-12-26(13-6-22)34-18-17-30-15-3-2-4-16-30/h5-14,19,32-33H,2-4,15-18,20H2,1H3

SMILES: Cc1c2cc(ccc2n(Cc2ccc(cc2)OCCN2CCCCC2)c1c1ccc(cc1)O)O

Synonyms:

• Pipendoxifene
• Era-923
• 2-(4-hydroxyphenyl)-3-methyl-1-[4-(2-piperidin-1-ylethoxy)benzyl]-1H-indol-5-ol

Pipendoxifene

CAS: 198480-55-6

Formula: C₂₉H₃₂N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 456.5760

Ref: IN-DA00AD6B

Pipendoxifene

CAS: 198480-55-6

Pipendoxifene (ERA-923) is an antiestrogen that blocks ER-alpha and inhibits MCF-7 breast cancer cell growth, effective even when tamoxifen-resistant.

Formula: C₂₉H₃₂N₂O₃

Color and Shape: Solid

Molecular weight: 456.58

Ref: TM-T70013

Pipendoxifene

Controlled Product

CAS: 198480-55-6

Applications Pipendoxifene is a 2-Ph indole selective estrogen receptor modulator (SERM) that exhibits an excellent preclin. pharmacol. profile and was selected for further development as a treatment for metastatic breast cancer.
References Cotreau, M., et al.: J. Clin. Pharm., 42, 157 (2002); Greenberger, L., et al.: Clin. Cancer Res., 7, 3166 (2001)

Formula: C₂₉H₃₂N₂O₃

Color and Shape: Neat

Molecular weight: 456.58

Ref: TR-P479850

Pipendoxifene (Piperidine-D10)

Controlled Product

CAS: 198480-55-6

Formula: C₂₉D₁₀H₂₂N₂O₃

Color and Shape: Neat

Molecular weight: 466.638

Ref: TR-P479911

Pipendoxifene

CAS: 198480-55-6

Pipendoxifene is a structural analogue of epidermal growth factor. It has been shown to have a therapeutic effect on bowel disease by binding to the epidermal growth factor receptor (EGFR) and stimulating cellular proliferation. Pipendoxifene also inhibits the production of inflammatory cytokines, such as tumor necrosis factor-α, and is an active form of polymerase chain reaction (PCR). The monoclonal antibodies against EGFR that are used in cancer therapy can be used in conjunction with pipendoxifene to improve their efficacy. Pipendoxifene has also been shown to have beneficial effects on diabetic neuropathy, which may be due to its ability to inhibit protein kinase C activity. Pipendoxifene has been shown to bind with high affinity to the breast cancer cell surface receptors and is a potential treatment for resistant breast cancer.

Formula: C₂₉H₃₂N₂O₃

Purity: Min. 95%

Molecular weight: 456.58 g/mol

Ref: 3D-FP176202