CAS 198481-33-3

Bazedoxifene acetate

Description:

Bazedoxifene acetate is a selective estrogen receptor modulator (SERM) primarily used in the treatment of postmenopausal osteoporosis and for the management of menopausal symptoms. It functions by mimicking estrogen in certain tissues, such as bone, while acting as an estrogen antagonist in others, such as breast and uterine tissues, thereby reducing the risk of estrogen-related side effects. The compound is characterized by its ability to bind selectively to estrogen receptors, promoting bone density without stimulating breast or uterine tissue proliferation. Bazedoxifene acetate is typically administered orally and is often combined with conjugated estrogens in therapeutic regimens. Its pharmacokinetics indicate a favorable absorption profile, with metabolism primarily occurring in the liver. The substance is known for its efficacy in reducing the incidence of vertebral fractures and improving overall bone health in postmenopausal women. As with any medication, potential side effects may include hot flashes, muscle spasms, and gastrointestinal disturbances, necessitating careful consideration of patient history and risk factors before prescribing.

Formula: C₃₀H₃₄N₂O₃·C₂H₄O₂

InChI: InChI=1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)

InChI key: InChIKey=OMZAMQFQZMUNTP-UHFFFAOYSA-N

SMILES: C(N1C(=C(C)C=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(OCCN5CCCCCC5)C=C4.C(C)(O)=O

Synonyms:

• 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate
• 1-(p-(2-(Hexahydro-1H-azepin-1-yl)ethoxy)benzyl)-2-(p-hydroxyphenyl)-3-methylindol-5-ol monoacetate (salt)
• 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate (1:1)
• 1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-, monoacetate (salt)
• 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, acetate (1:1)
• Tse 424
• Unii-J70472Ud3D
• Viviant
• Way-140424
• Way-Tes 424
• Bazedoxifene acetate

Bazedoxifene Acetate

CAS: 198481-33-3

Color and Shape: Neat

Ref: 61-FOR3342.00

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, acetate (1:1)

CAS: 198481-33-3

Formula: C₃₂H₃₈N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 530.6545

Ref: IN-DA002BJN

Bazedoxifene Acetate

CAS: 198481-33-3

Formula: C₃₀H₃₄N₂O₃·C₂H₄O₂

Color and Shape: Off-White Solid

Molecular weight: 470.61 60.05

Ref: 4Z-B-481

Bazedoxifene acetate

CAS: 198481-33-3

Formula: C₃₀H₃₄N₂O₃·C₂H₄O₂

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to beige powder

Molecular weight: 530.64

Ref: 7W-GP9413

Bazedoxifene Acetate

Controlled Product

CAS: 198481-33-3

Formula: C₃₀H₃₄N₂O₃·C₂H₄O₂

Color and Shape: Neat

Molecular weight: 530.65

Ref: 86-MM3342.00

Bazedoxifene acetate

CAS: 198481-33-3

Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).

Formula: C₃₂H₃₈N₂O₅

Purity: 99.24%

Color and Shape: Solid

Molecular weight: 530.67

Ref: TM-T2544

Bazedoxifene Acetate

CAS: 198481-33-3

Applications Bazedoxifene Acetate is a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic.
References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);

Formula: C₃₀H₃₄N₂O₃·C₂H₄O₂

Color and Shape: Neat

Molecular weight: 530.65

Ref: TR-B129250

Bazedoxifene acetate

Controlled Product

CAS: 198481-33-3

Bazedoxifene acetate is a selective estrogen receptor modulator (SERM) that prevents bone loss and reduces the risk of breast cancer in postmenopausal women. Bazedoxifene acetate has been shown to be safe and effective for the treatment of endometriosis, as it inhibits the growth of uterine tissue outside the uterus. Bazedoxifene acetate also acts on estrogen receptors in breast tissue and may be used to prevent breast cancer.

Formula: C₃₂H₃₈N₂O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 530.65 g/mol

Ref: 3D-FB45398

Bazedoxifene Acetate

CAS: 198481-33-3

Formula: C₃₀H₃₄N₂O₃C₂H₄O₂

Molecular weight: 470.62 : 60.05

Ref: ST-EA-CP-B41014