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CAS 198560-41-7

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FMOC-L-2-Chlorophe

Description:
FMOC-L-2-Chlorophenylalanine, identified by its CAS number 198560-41-7, is a derivative of the amino acid phenylalanine, where the phenyl group is substituted with a 2-chlorophenyl group and is protected by a 9-fluorenylmethoxycarbonyl (FMOC) group. This compound is primarily utilized in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), due to the FMOC group, which allows for selective protection and deprotection of the amino group. The presence of the chlorine atom in the 2-position of the phenyl ring can influence the compound's reactivity and steric properties, making it useful for introducing specific functionalities into peptides. FMOC-L-2-Chlorophenylalanine is typically a white to off-white solid and is soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Its applications extend to the development of pharmaceuticals and bioconjugates, where precise control over peptide structure is essential for biological activity. Proper handling and storage conditions are necessary to maintain its stability and efficacy in laboratory settings.
Formula:C24H20ClNO4
InChI:InChI=1/C24H20ClNO4/c25-21-12-6-1-7-15(21)13-22(23(27)28)26-24(29)30-14-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h1-12,20,22H,13-14H2,(H,26,29)(H,27,28)/t22-/m1/s1
SMILES:c1ccc(c(c1)C[C@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12)Cl
Synonyms:
  • Fmoc-L-2-Chlorophenylalanine
  • Fmoc-2-Chloro-L-phenylalanine
  • Fmoc-Phe(2-Cl)-OH
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