CAS 198561-07-8

FMOC-L-PROPARGYLGLYCINE

Description:

FMOC-L-propargylglycine is a chemical compound that serves as a building block in peptide synthesis and is particularly notable for its role in the development of bioorthogonal reactions. It features a fluorenylmethoxycarbonyl (FMOC) protecting group, which is commonly used to protect amino groups during peptide synthesis, allowing for selective reactions. The propargyl group in its structure introduces an alkyne functionality, enabling it to participate in click chemistry, particularly with azides, facilitating the formation of stable triazole linkages. This compound is typically utilized in research and pharmaceutical applications, especially in the synthesis of peptides that require specific modifications or functionalization. Its stability under standard laboratory conditions makes it a valuable reagent in organic synthesis. Additionally, FMOC-L-propargylglycine is characterized by its solubility in organic solvents, which is advantageous for various synthetic procedures. As with all chemical substances, proper handling and safety precautions should be observed due to potential hazards associated with its use.

Formula: C₂₀H₁₇NO₄

InChI: InChI=1/C20H17NO4/c1-2-7-18(19(22)23)21-20(24)25-12-17-15-10-5-3-8-13(15)14-9-4-6-11-16(14)17/h1,3-6,8-11,17-18H,7,12H2,(H,21,24)(H,22,23)/t18-/m1/s1

InChI key: InChIKey=DJGMNCKHNMRKFM-SFHVURJKSA-N

SMILES: C(OC(N[C@@H](CC#C)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pent-4-ynoic acid
• (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)pent-4-ynoic acid
• (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-pentynoic acid
• (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pent-4-ynoic acid
• (S)-2-(Fmoc-Amino)-4-Pentynoic Acid
• 4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-
• 4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (S)-
• Fmoc-(S)-2-Propargylglycine
• Fmoc-<span class="text-smallcaps">L</span>-propargylglycine
• Fmoc-Pra-Oh
• N-Alpha-(9-Fluorenylmethoxycarbonyl)-(S)-2-Amino-4-Pentynoic Acid
• N-Alpha-(9-Fluorenylmethoxycarbonyl)-Propargylglycine
• N-Alpha-(9-Fluorenylmethyloxycarbonyl)-L-Propargylglycine
• Rarechem Bk Pt 0257
• Fmoc-L-propargylglycine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-propargylglycine&gt
• FMOC-L-PROPARGYL-GLY-OH
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-propargylglycine
• (S)-N-FMoc-2-(2'-propynyl)glycine
• (S)-2-(Fmoc-amino)-4-pentynoic acid, Fmoc-L-2-propargylglycine
• Fmoc-Pra-OH Fmoc-Propargylglycine
• N-Fmoc-L-propargylglycine,95%
• (S)-N-(9-FLUORENYLMETHOXYCARBONYL)-2-AMINO-4-PENTYNOIC ACID
• FMOC-GLY(PROPARGYL)-OH
• Fmoc-L-propargylglycine Novabiochem
• Fmoc-L-propargylglycine≥ 99% (HPLC, Chiral purity)
• N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-propargylglycine, (S)-2-(Fmoc-amino)-4-pentynoic acid
• (S)-N-FMOC-PROPARGYLGLYCINE
• 4-Pentynoicacid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-
• N-FMoc-L-propargylglycine, 95%
• N-Fluorenemethoxycarbonyl-L-Propargyl Glycine
• L-2-Propargylglycine, N-FMOC protected
• (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)pent-4-ynoic acid
• FMOC-L-2-PROPARGYLGLYCINE
• FMoc-Propargyl-Gly-OH, (S)-2-(FMoc-aMino)-4-pentynoic acid
• FMOC-L-PRA-OH
• (S)-N-FMOC-Propargylglycine, 98% ee, 95%
• Fmoc-propargyl-Gly-OH
• (S)-2-(Fmoc-amino)-4-pentynoic
• (9H-Fluoren-9-yl)MethOxy]Carbonyl Pra-OH
• Fmoc-Pra-OH（Fmoc-Propargly-Gly-OH）
• (S)-N-fmoc-Propargylglycine(e.e.)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-propargylglycine

CAS: 198561-07-8

Formula: C₂₀H₁₇NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 335.36

Ref: 3B-F0926

N-Fmoc-L-propargylglycine, 95%

CAS: 198561-07-8

Fmoc-propargyl-Gly-OH is an Fmoc protected glycine derivative useful for solid phase peptide synthesis techniques. This compound could be useful as an unusual amino acid analog to aid in the deconvolution of protein structure and function. N-Fmoc-L-propargylglycine is a non-natural amino acids used

Formula: C₂₀H₁₇NO₄

Purity: 95%

Color and Shape: White, Powder

Molecular weight: 335.36

Ref: 02-H52171

Fmoc-L-propargylglycine

CAS: 198561-07-8

Formula: C₂₀H₁₇NO₄

Purity: 97%

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 335.359

Ref: 10-F492822

Fmoc-Pra-OH

CAS: 198561-07-8

Building block for the synthesis of precursor peptides for tritiation, and for “click chemistry”. Pra-containing peptides have been modified by 1,3-dipolar cycloaddition, e.g. with alkyl azides. Peptides containing a Pra residue and an α-azido acid have been cyclized in the presence of CuBr/Na-ascorbate via triazole formation. Educt for the synthesis of Phe-derivatives by rhodium-catalyzed [2+2+2] cycloaddition.

Formula: C₂₀H₁₇NO₄

Purity: 99.9%

Color and Shape: White

Molecular weight: 335.36

Ref: 01-4053914

4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-

CAS: 198561-07-8

Formula: C₂₀H₁₇NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 335.3533

Ref: IN-DA002BML

Fmoc-propargyl-Gly-OH

CAS: 198561-07-8

Formula: C₂₀H₁₇NO₄

Purity: ≥ 98.0%

Color and Shape: White to almost white powder or crystals

Molecular weight: 335.36

Ref: 7W-GM4391

L-2-Propargylglycine, N-FMOC protected

CAS: 198561-07-8

L-2-Propargylglycine, N-FMOC protected

Formula: C₂₀H₁₇NO₄

Purity: 98%

Color and Shape: off-white solid

Molecular weight: 335.35328g/mol

Ref: 54-OR14676

Fmoc-Pra-OH

CAS: 198561-07-8

Fmoc-Pra-OH is a bioconjugate used in Click Chemistry. Click Chemistry is a chemical reaction that joins two components together by forming an amide bond between the carboxyl group of one component and the amino group on the other component. Fmoc-Pra-OH was synthesized by reacting the epidermal growth factor (EGF) with a cyclic peptide containing an acid moiety, which was conjugated to the azide group of an azidopropargyl linker. This bioconjugate has been shown to have proliferative activity in vitro and structural studies have been performed to understand its reactivity.

Formula: C₂₀H₁₇NO₄

Purity: Min. 98.0 Area-%

Molecular weight: 335.36 g/mol

Ref: 3D-PRA-5010-PI

Fmoc-L-propargylglycine

CAS: 198561-07-8

Fmoc-L-propargylglycine is a cyclic peptide that is synthesized by chemical ligation. It has antiviral, anti-tumor, and anti-inflammatory activities. Fmoc-L-propargylglycine inhibits the growth of cancer cells in vitro. The mechanism of action is not fully understood, but it may involve the inhibition of cellular proliferation and the induction of apoptosis. This compound also inhibits epidermal growth factor (EGF) induced cell proliferation in caco-2 cells.

Formula: C₂₀H₁₇NO₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 335.35 g/mol

Ref: 3D-FF40126

Fmoc-l-propargylglycine

Controlled Product

CAS: 198561-07-8

Applications Fmoc-l-propargylglycine has been used to study the bioorthogonal chemical tagging of protein cholesterylation in living cells.
References William P. H., et al., ChemComm., 47, 4081-4083 (2011)

Formula: C₂₀H₁₇NO₄

Color and Shape: Neat

Molecular weight: 335.35

Ref: TR-F861030