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CAS 198976-06-6

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DIHYDRO-ARTEMISININ GLUCURONIDE

Description:
Dihydro-artemisinin glucuronide is a derivative of dihydroartemisinin, which is an active metabolite of artemisinin, a compound derived from the sweet wormwood plant, Artemisia annua. This glucuronide form is characterized by the addition of a glucuronic acid moiety, which enhances its solubility and bioavailability. Dihydro-artemisinin itself is known for its antimalarial properties, and the glucuronide form is believed to contribute to the pharmacokinetics of the drug, potentially influencing its efficacy and safety profile. The compound is typically studied for its role in malaria treatment, particularly in combination therapies. Its chemical structure includes multiple functional groups that contribute to its reactivity and interaction with biological systems. As a glucuronide, it is also subject to metabolic processes in the liver, where it may undergo further conjugation or hydrolysis. Overall, dihydro-artemisinin glucuronide represents an important aspect of artemisinin-based therapies, reflecting the ongoing research into optimizing antimalarial treatments.
Formula:C21H32O11
InChI:InChI=1/C21H32O11/c1-8-4-5-11-9(2)17(28-18-14(24)12(22)13(23)15(27-18)16(25)26)29-19-21(11)10(8)6-7-20(3,30-19)31-32-21/h8-15,17-19,22-24H,4-7H2,1-3H3,(H,25,26)/t8-,9-,10+,11+,12+,13+,14+,15?,17?,18+,19-,20-,21-/m1/s1
Synonyms:
  • (3R,5aS,6R,8aS,9S,12R,12aS)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl b-D-Glucopyranosiduronic Acid
  • Dihydro Artemisinin b-D-Glucuronide (Mixture of Isomers)
  • (3R,5aS,6R,8aS,9S,12R,12aS)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl -D-Glucopyranosiduronic Acid
  • Dihydro Artemisinin -D-Glucuronide (Mixture of Isomers)
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