Acerinol, with the CAS number 19902-53-5, is a chemical compound that belongs to the class of phenolic compounds. It is characterized by its aromatic structure, which typically includes a hydroxyl group (-OH) attached to a benzene ring. This functional group contributes to its solubility in polar solvents and its potential reactivity in various chemical reactions. Acerinol is often studied for its biological activities, including antioxidant properties, which may have implications in pharmaceutical applications. The compound may exhibit moderate toxicity, and its handling requires appropriate safety measures. In terms of physical properties, it may present as a solid or liquid at room temperature, depending on its specific formulation and purity. Its applications can range from use in organic synthesis to potential roles in medicinal chemistry, although detailed studies on its efficacy and safety are essential for any practical applications. As with any chemical substance, proper characterization and understanding of its properties are crucial for safe and effective use.

Acerinol is a an active ingredient from traditional Chinese medicinal herbs that could be used as a cancer multidrug resistance reversal agent. Specifically, acerinol has been implicated in reversing resistance to the drugs that cause overexpression of the ABCB1 family of ATP-binding cassettes. Acerinol could increase the chemosensitivity of ABCB1-overexpressing HepG2/ADM and MCF-7/ADR cells to chemotherapeutic drugs, doxorubicin, vincristine and paclitaxel. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affecting the expression of ABCB1 on neither mRNA nor protein level.  Acerinol from C. acerina significantly enhances the cytotoxicity of chemotherapeutic drugs by modulating the function of ABCB1.

Acerinol

19902-53-5: Acerinol, with the CAS number 19902-53-5, is a chemical compound that belongs to the class of phenolic compounds. It is characterized by its aromatic structure, which typically includes a hydroxyl group (-OH) attached to a benzene ring. This functional group contributes to its solubility in polar solvents and its potential reactivity in various chemical reactions. Acerinol is often studied for its biological activities, including antioxidant properties, which may have implications in pharmaceutical applications. The compound may exhibit moderate toxicity, and its handling requires appropriate safety measures. In terms of physical properties, it may present as a solid or liquid at room temperature, depending on its specific formulation and purity. Its applications can range from use in organic synthesis to potential roles in medicinal chemistry, although detailed studies on its efficacy and safety are essential for any practical applications. As with any chemical substance, proper characterization and understanding of its properties are crucial for safe and effective use.

Acerinol, from Chinese herbs, may reverse cancer drug resistance, boosting ABCB1 ATPase, not altering its mRNA/protein expression.

CAS 19902-53-5

Acerinol

Acerinol

Ref: TM-T23610